A substrate-based difluoro ketone selectively inhibits Alzheimer's gamma-secretase activity

J Med Chem. 1998 Jan 1;41(1):6-9. doi: 10.1021/jm970621b.
No abstract available

Publication types

  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Alzheimer Disease / enzymology*
  • Amino Acid Sequence
  • Amyloid Precursor Protein Secretases
  • Amyloid beta-Peptides / metabolism
  • Amyloid beta-Protein Precursor / metabolism
  • Animals
  • Aspartic Acid Endopeptidases
  • CHO Cells
  • Cricetinae
  • Endopeptidases / metabolism*
  • Humans
  • Ketones / chemical synthesis
  • Ketones / chemistry*
  • Ketones / pharmacology
  • Oligopeptides / chemical synthesis
  • Oligopeptides / chemistry*
  • Oligopeptides / pharmacology
  • Protease Inhibitors / chemical synthesis
  • Protease Inhibitors / chemistry*
  • Protease Inhibitors / pharmacology
  • Recombinant Proteins / antagonists & inhibitors
  • Substrate Specificity
  • Transfection

Substances

  • Amyloid beta-Peptides
  • Amyloid beta-Protein Precursor
  • Ketones
  • Oligopeptides
  • Protease Inhibitors
  • Recombinant Proteins
  • Amyloid Precursor Protein Secretases
  • Endopeptidases
  • Aspartic Acid Endopeptidases
  • BACE1 protein, human