Abstract
Four phenylethanoids isolated from the stems of Cistanche deserticola, acteoside (1), 2'-acetylacteoside (2), isoacteoside (3) and tubuloside B (4), significantly suppressed NADPH/CCl4-induced lipid peroxidation in rat liver microsomes. Addition of them to primary cultured rat hepatocytes efficiently prevented cell damage induced by exposure to CCl4 or D-galactosamine (D-GalN). Acteoside (1) further showed pronounced anti-hepatotoxic activity against CCl4 in vivo.
MeSH terms
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Animals
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Carbon Tetrachloride / antagonists & inhibitors
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Carbon Tetrachloride / toxicity*
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Cell Survival / drug effects
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Cells, Cultured
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Glucosides / chemistry
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Glucosides / isolation & purification*
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Glucosides / pharmacology
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Lipid Peroxidation / drug effects
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Liver / cytology
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Liver / drug effects*
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Liver / pathology
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Male
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Medicine, Chinese Traditional
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Microsomes, Liver / drug effects
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Microsomes, Liver / metabolism
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Molecular Structure
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Phenols*
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Plant Extracts*
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Plants, Medicinal*
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Rats
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Rats, Wistar
Substances
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2'-acetylacteoside
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Glucosides
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Phenols
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Plant Extracts
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tubuloside B
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acteoside
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isoacteoside
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Carbon Tetrachloride