Abstract
We studied the effects of FGF-13 and FGF-2 on human lung fibroblasts, dermal microvascular endothelial cells, and aortic smooth muscle cells. FGF-13 induced cell growth of lung fibroblasts and aortic smooth muscle cells but had no effect on dermal vascular endothelial cells. FGF-2 induced cell growth in all the three cell types. FGF-13 and FGF-2 had little effect on IL-6 production by lung fibroblasts and aortic smooth muscle cells and substantially enhanced that induced by IL-1alpha. In contrast, FGF-13 and FGF-2 had little effect on IL-6 production by dermal vascular endothelial cells, either alone or in synergy with IL-1alpha.
Copyright 1998 Academic Press.
MeSH terms
-
Aorta / cytology
-
Aorta / drug effects*
-
Aorta / metabolism
-
Cell Division / drug effects
-
Cells, Cultured
-
Dinoprostone / metabolism
-
Endothelium, Vascular / cytology
-
Endothelium, Vascular / drug effects*
-
Endothelium, Vascular / metabolism
-
Fibroblast Growth Factor 2 / pharmacology
-
Fibroblast Growth Factors / pharmacology*
-
Fibroblasts / cytology
-
Fibroblasts / drug effects
-
Fibroblasts / metabolism
-
Humans
-
Interleukin-1 / pharmacology
-
Interleukin-6 / metabolism
-
Lung / cytology
-
Lung / drug effects*
-
Lung / metabolism
-
Muscle, Smooth, Vascular / cytology
-
Muscle, Smooth, Vascular / drug effects*
-
Muscle, Smooth, Vascular / metabolism
Substances
-
Interleukin-1
-
Interleukin-6
-
Fibroblast Growth Factor 2
-
fibroblast growth factor 13
-
Fibroblast Growth Factors
-
Dinoprostone