Prevention of DOI-mediated wet dog shakes by inhibitors of nitric oxide synthase

Brain Res. 1998 Sep 7;804(2):337-40. doi: 10.1016/s0006-8993(98)00682-9.

Abstract

The purpose of this study was to determine if (+/-)-1-(2, 5-dimethoxy-4-iodophenyl)-2-aminopropane (DOI)-induced wet dog shakes (WDS) required the involvement of nitric oxide synthases (NOS). Systemic administration of the general NOS inhibitor NG-nitro-L-arginine methyl ester (L-NAME), but not its d-isomer, and the neuronal NOS (nNOS) inhibitor 7-nitroindazole completely blocked DOI-mediated WDS in a dose dependent manner. The data provides evidence that serotonin 5HT2 receptors are coupled to nNOS activation in the rat brain.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Amphetamines / antagonists & inhibitors*
  • Amphetamines / toxicity
  • Animals
  • Behavior, Animal / drug effects*
  • Enzyme Inhibitors / pharmacology*
  • Indazoles / pharmacology
  • Isoenzymes / antagonists & inhibitors
  • Isoenzymes / metabolism
  • Male
  • NG-Nitroarginine Methyl Ester / pharmacology
  • Nitric Oxide Synthase / antagonists & inhibitors*
  • Nitric Oxide Synthase Type I
  • Rats
  • Rats, Sprague-Dawley
  • Serotonin Receptor Agonists / toxicity*

Substances

  • Amphetamines
  • Enzyme Inhibitors
  • Indazoles
  • Isoenzymes
  • Serotonin Receptor Agonists
  • Nitric Oxide Synthase
  • Nitric Oxide Synthase Type I
  • Nos1 protein, rat
  • 4-iodo-2,5-dimethoxyphenylisopropylamine
  • 7-nitroindazole
  • NG-Nitroarginine Methyl Ester