Abstract
The purpose of this study was to determine if (+/-)-1-(2, 5-dimethoxy-4-iodophenyl)-2-aminopropane (DOI)-induced wet dog shakes (WDS) required the involvement of nitric oxide synthases (NOS). Systemic administration of the general NOS inhibitor NG-nitro-L-arginine methyl ester (L-NAME), but not its d-isomer, and the neuronal NOS (nNOS) inhibitor 7-nitroindazole completely blocked DOI-mediated WDS in a dose dependent manner. The data provides evidence that serotonin 5HT2 receptors are coupled to nNOS activation in the rat brain.
Copyright 1998 Published by Elsevier Science B.V.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Amphetamines / antagonists & inhibitors*
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Amphetamines / toxicity
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Animals
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Behavior, Animal / drug effects*
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Enzyme Inhibitors / pharmacology*
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Indazoles / pharmacology
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Isoenzymes / antagonists & inhibitors
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Isoenzymes / metabolism
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Male
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NG-Nitroarginine Methyl Ester / pharmacology
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Nitric Oxide Synthase / antagonists & inhibitors*
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Nitric Oxide Synthase Type I
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Rats
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Rats, Sprague-Dawley
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Serotonin Receptor Agonists / toxicity*
Substances
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Amphetamines
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Enzyme Inhibitors
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Indazoles
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Isoenzymes
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Serotonin Receptor Agonists
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Nitric Oxide Synthase
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Nitric Oxide Synthase Type I
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Nos1 protein, rat
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4-iodo-2,5-dimethoxyphenylisopropylamine
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7-nitroindazole
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NG-Nitroarginine Methyl Ester