Mutational evidence for a common kappa antagonist binding pocket in the wild-type kappa and mutant mu[K303E] opioid receptors

MeSH terms

• Amino Acid Sequence
• Animals
• Binding, Competitive
• COS Cells
• Guanidines
• Guinea Pigs
• Ileum / drug effects
• In Vitro Techniques
• Male
• Mice
• Models, Molecular
• Molecular Conformation
• Molecular Sequence Data
• Morphinans
• Muscle, Smooth / drug effects
• Mutation
• Naltrexone / analogs & derivatives*
• Naltrexone / chemical synthesis
• Naltrexone / metabolism
• Naltrexone / pharmacology
• Narcotic Antagonists / chemical synthesis*
• Narcotic Antagonists / metabolism
• Narcotic Antagonists / pharmacology
• Rats
• Receptors, Opioid, kappa / antagonists & inhibitors*
• Receptors, Opioid, kappa / metabolism
• Receptors, Opioid, mu / genetics*
• Receptors, Opioid, mu / metabolism*
• Vas Deferens / drug effects