Abstract
The synthesis of a photolyzable sphingosine 1-phosphate derivative is reported via the reaction of N-(tert-butoxycarbonyl)-2-N,3-O- isopropylidenesphingosine 7 and bis(alpha-methyl-o-nitrobenzyl) N,N-diisopropyl-phosphoramidite. Stimulation of DNA synthesis upon illumination of caged SPP-loaded cells is also described.
Publication types
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, Non-P.H.S.
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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3T3 Cells
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Animals
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Cell Division / drug effects
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DNA / biosynthesis*
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Indicators and Reagents
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Lysophospholipids*
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Mice
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Models, Molecular
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Molecular Structure
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Organophosphates / chemical synthesis*
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Organophosphates / chemistry
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Organophosphates / pharmacology
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Photolysis
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Sphingosine / analogs & derivatives*
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Sphingosine / chemical synthesis
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Sphingosine / chemistry
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Sphingosine / pharmacology
Substances
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Indicators and Reagents
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Lysophospholipids
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Organophosphates
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caged sphingosine 1-phosphate
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sphingosine 1-phosphate
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DNA
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Sphingosine