Abstract
Eleven betulin derivatives were prepared and evaluated for anti-HIV activity in H9 lymphocytes. Compound 4 was found to be the most active with EC50 and TI values of 0.00066 microM and 21,515, respectively.
Publication types
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Anti-HIV Agents / chemical synthesis*
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Anti-HIV Agents / chemistry
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Anti-HIV Agents / pharmacology
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Cell Line
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Cell Survival / drug effects
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Drug Design
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HIV-1 / drug effects*
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Humans
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Lymphocytes / drug effects
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Lymphocytes / virology
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Molecular Structure
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Structure-Activity Relationship
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Triterpenes* / chemical synthesis*
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Triterpenes* / chemistry
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Triterpenes* / pharmacology
Substances
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Anti-HIV Agents
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Triterpenes
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betulin