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Page 1
PXR-mediated idiosyncratic drug-induced liver injury: mechanistic insights and targeting approaches.
Expert Opin Drug Metab Toxicol. 2020 Aug;16(8):711-722. doi: 10.1080/17425255.2020.1779701. Epub 2020 Jun 16.
Expert Opin Drug Metab Toxicol. 2020.
PMID: 32500752
Free PMC article.
Review.
A New Strategy to Control and Eradicate "Undruggable" Oncogenic K-RAS-Driven Pancreatic Cancer: Molecular Insights and Core Principles Learned from Developmental and Evolutionary Biology.
Van Sciver RE, Lee MP, Lee CD, Lafever AC, Svyatova E, Kanda K, Colliver AL, Siewertsz van Reesema LL, Tang-Tan AM, Zheleva V, Bwayi MN, Bian M, Schmidt RL, Matrisian LM, Petersen GM, Tang AH.
Van Sciver RE, et al. Among authors: bwayi mn.
Cancers (Basel). 2018 May 14;10(5):142. doi: 10.3390/cancers10050142.
Cancers (Basel). 2018.
PMID: 29757973
Free PMC article.
Review.
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CITCO Directly Binds to and Activates Human Pregnane X Receptor.
Lin W, Bwayi M, Wu J, Li Y, Chai SC, Huber AD, Chen T.
Lin W, et al. Among authors: bwayi m.
Mol Pharmacol. 2020 Mar;97(3):180-190. doi: 10.1124/mol.119.118513. Epub 2019 Dec 27.
Mol Pharmacol. 2020.
PMID: 31882411
Free PMC article.
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Molecular basis of crosstalk in nuclear receptors: heterodimerization between PXR and CAR and the implication in gene regulation.
Bwayi MN, Garcia-Maldonado E, Chai SC, Xie B, Chodankar S, Huber AD, Wu J, Annu K, Wright WC, Lee HM, Seetharaman J, Wang J, Buchman CD, Peng J, Chen T.
Bwayi MN, et al.
Nucleic Acids Res. 2022 Apr 8;50(6):3254-3275. doi: 10.1093/nar/gkac133.
Nucleic Acids Res. 2022.
PMID: 35212371
Free PMC article.
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A bromodomain-independent mechanism of gene regulation by the BET inhibitor JQ1: direct activation of nuclear receptor PXR.
Huber AD, Poudel S, Wu J, Miller DJ, Lin W, Yang L, Bwayi MN, Rimmer MA, Gee RRF, Seetharaman J, Chai SC, Chen T.
Huber AD, et al. Among authors: bwayi mn.
Nucleic Acids Res. 2024 Feb 28;52(4):1661-1676. doi: 10.1093/nar/gkad1175.
Nucleic Acids Res. 2024.
PMID: 38084912
Free PMC article.
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