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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1980 2
1982 1
1983 3
1984 3
1985 4
1987 4
1988 5
1989 3
1990 5
1991 4
1992 8
1993 8
1994 14
1995 6
1996 9
1997 11
1998 3
1999 10
2000 12
2001 8
2002 4
2003 7
2004 7
2005 7
2006 6
2007 8
2008 5
2010 3
2011 3
2012 4
2013 6
2014 7
2015 5
2016 5
2017 4
2018 9
2019 7
2020 7
2021 2
2022 4
2023 2
2024 2

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227 results

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Page 1
Drugging the undruggable RAS: Mission possible?
Cox AD, Fesik SW, Kimmelman AC, Luo J, Der CJ. Cox AD, et al. Among authors: fesik sw. Nat Rev Drug Discov. 2014 Nov;13(11):828-51. doi: 10.1038/nrd4389. Epub 2014 Oct 17. Nat Rev Drug Discov. 2014. PMID: 25323927 Free PMC article. Review.
Drugging an undruggable pocket on KRAS.
Kessler D, Gmachl M, Mantoulidis A, Martin LJ, Zoephel A, Mayer M, Gollner A, Covini D, Fischer S, Gerstberger T, Gmaschitz T, Goodwin C, Greb P, Häring D, Hela W, Hoffmann J, Karolyi-Oezguer J, Knesl P, Kornigg S, Koegl M, Kousek R, Lamarre L, Moser F, Munico-Martinez S, Peinsipp C, Phan J, Rinnenthal J, Sai J, Salamon C, Scherbantin Y, Schipany K, Schnitzer R, Schrenk A, Sharps B, Siszler G, Sun Q, Waterson A, Wolkerstorfer B, Zeeb M, Pearson M, Fesik SW, McConnell DB. Kessler D, et al. Among authors: fesik sw. Proc Natl Acad Sci U S A. 2019 Aug 6;116(32):15823-15829. doi: 10.1073/pnas.1904529116. Epub 2019 Jul 22. Proc Natl Acad Sci U S A. 2019. PMID: 31332011 Free PMC article.
MYC and MCL1 Cooperatively Promote Chemotherapy-Resistant Breast Cancer Stem Cells via Regulation of Mitochondrial Oxidative Phosphorylation.
Lee KM, Giltnane JM, Balko JM, Schwarz LJ, Guerrero-Zotano AL, Hutchinson KE, Nixon MJ, Estrada MV, Sánchez V, Sanders ME, Lee T, Gómez H, Lluch A, Pérez-Fidalgo JA, Wolf MM, Andrejeva G, Rathmell JC, Fesik SW, Arteaga CL. Lee KM, et al. Among authors: fesik sw. Cell Metab. 2017 Oct 3;26(4):633-647.e7. doi: 10.1016/j.cmet.2017.09.009. Cell Metab. 2017. PMID: 28978427 Free PMC article.
Targeting MYC through WDR5.
Thomas LR, Adams CM, Fesik SW, Eischen CM, Tansey WP. Thomas LR, et al. Among authors: fesik sw. Mol Cell Oncol. 2020 Jan 10;7(2):1709388. doi: 10.1080/23723556.2019.1709388. eCollection 2020. Mol Cell Oncol. 2020. PMID: 32158922 Free PMC article.
Fragment-based drug discovery using NMR spectroscopy.
Harner MJ, Frank AO, Fesik SW. Harner MJ, et al. Among authors: fesik sw. J Biomol NMR. 2013 Jun;56(2):65-75. doi: 10.1007/s10858-013-9740-z. Epub 2013 May 18. J Biomol NMR. 2013. PMID: 23686385 Free PMC article. Review.
NMR-based screening in drug discovery.
Hajduk PJ, Meadows RP, Fesik SW. Hajduk PJ, et al. Among authors: fesik sw. Q Rev Biophys. 1999 Aug;32(3):211-40. doi: 10.1017/s0033583500003528. Q Rev Biophys. 1999. PMID: 11194565 Review. No abstract available.
Small molecule Mcl-1 inhibitors for the treatment of cancer.
Belmar J, Fesik SW. Belmar J, et al. Among authors: fesik sw. Pharmacol Ther. 2015 Jan;145:76-84. doi: 10.1016/j.pharmthera.2014.08.003. Epub 2014 Aug 27. Pharmacol Ther. 2015. PMID: 25172548 Free PMC article. Review.
Targeting WDR5: A WINning Anti-Cancer Strategy?
Aho ER, Weissmiller AM, Fesik SW, Tansey WP. Aho ER, et al. Among authors: fesik sw. Epigenet Insights. 2019 Jul 18;12:2516865719865282. doi: 10.1177/2516865719865282. eCollection 2019. Epigenet Insights. 2019. PMID: 31360909 Free PMC article.
Twenty years on: the impact of fragments on drug discovery.
Erlanson DA, Fesik SW, Hubbard RE, Jahnke W, Jhoti H. Erlanson DA, et al. Among authors: fesik sw. Nat Rev Drug Discov. 2016 Sep;15(9):605-619. doi: 10.1038/nrd.2016.109. Epub 2016 Jul 15. Nat Rev Drug Discov. 2016. PMID: 27417849 Review.
227 results