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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1967 1
1973 1
1977 1
1979 3
1982 2
1983 2
1984 1
1985 2
1986 1
1987 2
1988 1
1989 5
1990 4
1992 7
1993 9
1994 5
1995 2
1996 2
1997 1
1998 7
1999 2
2000 2
2001 3
2003 1
2004 3
2005 1
2006 10
2007 7
2008 3
2009 3
2011 1
2013 1
2014 2
2015 2
2016 1
2017 4
2018 4
2019 2
2020 1
2023 1
2024 0

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108 results

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Page 1
Small-molecule factor B inhibitor for the treatment of complement-mediated diseases.
Schubart A, Anderson K, Mainolfi N, Sellner H, Ehara T, Adams CM, Mac Sweeney A, Liao SM, Crowley M, Littlewood-Evans A, Sarret S, Wieczorek G, Perrot L, Dubost V, Flandre T, Zhang Y, Smith RJH, Risitano AM, Karki RG, Zhang C, Valeur E, Sirockin F, Gerhartz B, Erbel P, Hughes N, Smith TM, Cumin F, Argikar UA, Haraldsson B, Mogi M, Sedrani R, Wiesmann C, Jaffee B, Maibaum J, Flohr S, Harrison R, Eder J. Schubart A, et al. Among authors: jaffee b. Proc Natl Acad Sci U S A. 2019 Apr 16;116(16):7926-7931. doi: 10.1073/pnas.1820892116. Epub 2019 Mar 29. Proc Natl Acad Sci U S A. 2019. PMID: 30926668 Free PMC article.
Complement factor B is critical for sub-RPE deposit accumulation in a model of Doyne honeycomb retinal dystrophy with features of age-related macular degeneration.
Crowley MA, Garland DL, Sellner H, Banks A, Fan L, Rejtar T, Buchanan N, Delgado O, Xu YY, Jose S, Adams CM, Mogi M, Wang K, Bigelow CE, Poor S, Anderson K, Jaffee BD, Prasanna G, Grosskreutz C, Fernandez-Godino R, Pierce EA, Dryja TP, Liao SM. Crowley MA, et al. Among authors: jaffee bd. Hum Mol Genet. 2023 Jan 6;32(2):204-217. doi: 10.1093/hmg/ddac187. Hum Mol Genet. 2023. PMID: 35943778 Free PMC article.
Discovery of 4-((2S,4S)-4-Ethoxy-1-((5-methoxy-7-methyl-1H-indol-4-yl)methyl)piperidin-2-yl)benzoic Acid (LNP023), a Factor B Inhibitor Specifically Designed To Be Applicable to Treating a Diverse Array of Complement Mediated Diseases.
Mainolfi N, Ehara T, Karki RG, Anderson K, Mac Sweeney A, Liao SM, Argikar UA, Jendza K, Zhang C, Powers J, Klosowski DW, Crowley M, Kawanami T, Ding J, April M, Forster C, Serrano-Wu M, Capparelli M, Ramqaj R, Solovay C, Cumin F, Smith TM, Ferrara L, Lee W, Long D, Prentiss M, De Erkenez A, Yang L, Liu F, Sellner H, Sirockin F, Valeur E, Erbel P, Ostermeier D, Ramage P, Gerhartz B, Schubart A, Flohr S, Gradoux N, Feifel R, Vogg B, Wiesmann C, Maibaum J, Eder J, Sedrani R, Harrison RA, Mogi M, Jaffee BD, Adams CM. Mainolfi N, et al. Among authors: jaffee bd. J Med Chem. 2020 Jun 11;63(11):5697-5722. doi: 10.1021/acs.jmedchem.9b01870. Epub 2020 Feb 19. J Med Chem. 2020. PMID: 32073845
Brequinar sodium: monitoring immunosuppressive activity.
Eiras-Hreha G, Cramer DV, Cosenza C, Chapman FA, Mills L, Cajulis E, Hill D, Jones E, Zajac I, Jaffee B, et al. Eiras-Hreha G, et al. Among authors: jaffee b. Transplant Proc. 1993 Jun;25(3 Suppl 2):32-6. Transplant Proc. 1993. PMID: 8516940 Review.
Long-acting protein drugs for the treatment of ocular diseases.
Ghosh JG, Nguyen AA, Bigelow CE, Poor S, Qiu Y, Rangaswamy N, Ornberg R, Jackson B, Mak H, Ezell T, Kenanova V, de la Cruz E, Carrion A, Etemad-Gilbertson B, Caro RG, Zhu K, George V, Bai J, Sharma-Nahar R, Shen S, Wang Y, Subramanian KK, Fassbender E, Maker M, Hanks S, Vrouvlianis J, Leehy B, Long D, Prentiss M, Kansara V, Jaffee B, Dryja TP, Roguska M. Ghosh JG, et al. Among authors: jaffee b. Nat Commun. 2017 Mar 23;8:14837. doi: 10.1038/ncomms14837. Nat Commun. 2017. PMID: 28332616 Free PMC article.
Small-molecule factor D inhibitors targeting the alternative complement pathway.
Maibaum J, Liao SM, Vulpetti A, Ostermann N, Randl S, Rüdisser S, Lorthiois E, Erbel P, Kinzel B, Kolb FA, Barbieri S, Wagner J, Durand C, Fettis K, Dussauge S, Hughes N, Delgado O, Hommel U, Gould T, Mac Sweeney A, Gerhartz B, Cumin F, Flohr S, Schubart A, Jaffee B, Harrison R, Risitano AM, Eder J, Anderson K. Maibaum J, et al. Among authors: jaffee b. Nat Chem Biol. 2016 Dec;12(12):1105-1110. doi: 10.1038/nchembio.2208. Epub 2016 Oct 24. Nat Chem Biol. 2016. PMID: 27775713
Immunoregulation workshop.
Benjamin WR, Jaffee B. Benjamin WR, et al. Among authors: jaffee b. Agents Actions Suppl. 1993;41:191-3. Agents Actions Suppl. 1993. PMID: 8100390 No abstract available.
Nonclinical Safety Evaluation of scAAV8-RLBP1 for Treatment of RLBP1 Retinitis Pigmentosa.
MacLachlan TK, Milton MN, Turner O, Tukov F, Choi VW, Penraat J, Delmotte MH, Michaut L, Jaffee BD, Bigelow CE. MacLachlan TK, et al. Among authors: jaffee bd. Mol Ther Methods Clin Dev. 2017 Dec 22;8:105-120. doi: 10.1016/j.omtm.2017.12.001. eCollection 2018 Mar 16. Mol Ther Methods Clin Dev. 2017. PMID: 29359172 Free PMC article.
Design, Synthesis, and Preclinical Characterization of Selective Factor D Inhibitors Targeting the Alternative Complement Pathway.
Karki RG, Powers J, Mainolfi N, Anderson K, Belanger DB, Liu D, Ji N, Jendza K, Gelin CF, Mac Sweeney A, Solovay C, Delgado O, Crowley M, Liao SM, Argikar UA, Flohr S, La Bonte LR, Lorthiois EL, Vulpetti A, Brown A, Long D, Prentiss M, Gradoux N, de Erkenez A, Cumin F, Adams C, Jaffee B, Mogi M. Karki RG, et al. Among authors: jaffee b. J Med Chem. 2019 May 9;62(9):4656-4668. doi: 10.1021/acs.jmedchem.9b00271. Epub 2019 Apr 30. J Med Chem. 2019. PMID: 30995036
Lack of involvement of CEP adducts in TLR activation and in angiogenesis.
Gounarides J, Cobb JS, Zhou J, Cook F, Yang X, Yin H, Meredith E, Rao C, Huang Q, Xu Y, Anderson K, De Erkenez A, Liao SM, Crowley M, Buchanan N, Poor S, Qiu Y, Fassbender E, Shen S, Woolfenden A, Jensen A, Cepeda R, Etemad-Gilbertson B, Giza S, Mogi M, Jaffee B, Azarian S. Gounarides J, et al. Among authors: jaffee b. PLoS One. 2014 Oct 24;9(10):e111472. doi: 10.1371/journal.pone.0111472. eCollection 2014. PLoS One. 2014. PMID: 25343517 Free PMC article.
108 results