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Pharmacological Properties of DOV 315,090, an ocinaplon metabolite.
Berezhnoy D, Gravielle MC, Downing S, Kostakis E, Basile AS, Skolnick P, Gibbs TT, Farb DH. Berezhnoy D, et al. Among authors: kostakis e. BMC Pharmacol. 2008 Jun 13;8:11. doi: 10.1186/1471-2210-8-11. BMC Pharmacol. 2008. PMID: 18554397 Free PMC article.
Selective anxiolysis produced by ocinaplon, a GABA(A) receptor modulator.
Lippa A, Czobor P, Stark J, Beer B, Kostakis E, Gravielle M, Bandyopadhyay S, Russek SJ, Gibbs TT, Farb DH, Skolnick P. Lippa A, et al. Among authors: kostakis e. Proc Natl Acad Sci U S A. 2005 May 17;102(20):7380-5. doi: 10.1073/pnas.0502579102. Epub 2005 May 3. Proc Natl Acad Sci U S A. 2005. PMID: 15870187 Free PMC article. Clinical Trial.
The anxioselective agent 7-(2-chloropyridin-4-yl)pyrazolo-[1,5-a]-pyrimidin-3-yl](pyridin-2-yl)methanone (DOV 51892) is more efficacious than diazepam at enhancing GABA-gated currents at alpha1 subunit-containing GABAA receptors.
Popik P, Kostakis E, Krawczyk M, Nowak G, Szewczyk B, Krieter P, Chen Z, Russek SJ, Gibbs TT, Farb DH, Skolnick P, Lippa AS, Basile AS. Popik P, et al. Among authors: kostakis e. J Pharmacol Exp Ther. 2006 Dec;319(3):1244-52. doi: 10.1124/jpet.106.107201. Epub 2006 Sep 13. J Pharmacol Exp Ther. 2006. PMID: 16971504