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Hedgehog-producing cancer cells respond to and require autocrine Hedgehog activity.
Singh S, Wang Z, Liang Fei D, Black KE, Goetz JA, Tokhunts R, Giambelli C, Rodriguez-Blanco J, Long J, Lee E, Briegel KJ, Bejarano PA, Dmitrovsky E, Capobianco AJ, Robbins DJ. Singh S, et al. Among authors: liang fei d. Cancer Res. 2011 Jul 1;71(13):4454-63. doi: 10.1158/0008-5472.CAN-10-2313. Epub 2011 May 12. Cancer Res. 2011. PMID: 21565978 Free PMC article.
The hedgehog processing pathway is required for NSCLC growth and survival.
Rodriguez-Blanco J, Schilling NS, Tokhunts R, Giambelli C, Long J, Liang Fei D, Singh S, Black KE, Wang Z, Galimberti F, Bejarano PA, Elliot S, Glassberg MK, Nguyen DM, Lockwood WW, Lam WL, Dmitrovsky E, Capobianco AJ, Robbins DJ. Rodriguez-Blanco J, et al. Among authors: liang fei d. Oncogene. 2013 May 2;32(18):2335-45. doi: 10.1038/onc.2012.243. Epub 2012 Jun 25. Oncogene. 2013. PMID: 22733134 Free PMC article.