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Page 1
Development of improved PPARβ/δ inhibitors.
ChemMedChem. 2012 Jan 2;7(1):159-70. doi: 10.1002/cmdc.201100408. Epub 2011 Oct 24.
ChemMedChem. 2012.
PMID: 22025402
(Z)-2-(2-bromophenyl)-3-{[4-(1-methyl-piperazine)amino]phenyl}acrylonitrile (DG172): an orally bioavailable PPARβ/δ-selective ligand with inverse agonistic properties.
Lieber S, Scheer F, Meissner W, Naruhn S, Adhikary T, Müller-Brüsselbach S, Diederich WE, Müller R.
Lieber S, et al. Among authors: naruhn s.
J Med Chem. 2012 Mar 22;55(6):2858-68. doi: 10.1021/jm2017122. Epub 2012 Mar 8.
J Med Chem. 2012.
PMID: 22369181
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15-hydroxyeicosatetraenoic acid is a preferential peroxisome proliferator-activated receptor beta/delta agonist.
Naruhn S, Meissner W, Adhikary T, Kaddatz K, Klein T, Watzer B, Müller-Brüsselbach S, Müller R.
Naruhn S, et al.
Mol Pharmacol. 2010 Feb;77(2):171-84. doi: 10.1124/mol.109.060541. Epub 2009 Nov 10.
Mol Pharmacol. 2010.
PMID: 19903832
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Cellular and pharmacological selectivity of the peroxisome proliferator-activated receptor-beta/delta antagonist GSK3787.
Palkar PS, Borland MG, Naruhn S, Ferry CH, Lee C, Sk UH, Sharma AK, Amin S, Murray IA, Anderson CR, Perdew GH, Gonzalez FJ, Müller R, Peters JM.
Palkar PS, et al. Among authors: naruhn s.
Mol Pharmacol. 2010 Sep;78(3):419-30. doi: 10.1124/mol.110.065508. Epub 2010 Jun 1.
Mol Pharmacol. 2010.
PMID: 20516370
Free PMC article.
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High-affinity peroxisome proliferator-activated receptor β/δ-specific ligands with pure antagonistic or inverse agonistic properties.
Naruhn S, Toth PM, Adhikary T, Kaddatz K, Pape V, Dörr S, Klebe G, Müller-Brüsselbach S, Diederich WE, Müller R.
Naruhn S, et al.
Mol Pharmacol. 2011 Nov;80(5):828-38. doi: 10.1124/mol.111.074039. Epub 2011 Aug 23.
Mol Pharmacol. 2011.
PMID: 21862691
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Inverse PPARβ/δ agonists suppress oncogenic signaling to the ANGPTL4 gene and inhibit cancer cell invasion.
Adhikary T, Brandt DT, Kaddatz K, Stockert J, Naruhn S, Meissner W, Finkernagel F, Obert J, Lieber S, Scharfe M, Jarek M, Toth PM, Scheer F, Diederich WE, Reinartz S, Grosse R, Müller-Brüsselbach S, Müller R.
Adhikary T, et al. Among authors: naruhn s.
Oncogene. 2013 Oct 31;32(44):5241-52. doi: 10.1038/onc.2012.549. Epub 2012 Dec 3.
Oncogene. 2013.
PMID: 23208498
Free PMC article.
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