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'Targeted' molecular diversity: design and development of non-peptide antagonists for cholecystokinin and tachykinin receptors.
Immunopharmacology. 1996 Jun;33(1-3):68-72. doi: 10.1016/0162-3109(96)00058-6.
Immunopharmacology. 1996.
PMID: 8856117
Review.
Use of a dipeptide chemical library in the development of non-peptide tachykinin NK3 receptor selective antagonists.
Boden P, Eden JM, Hodgson J, Horwell DC, Hughes J, McKnight AT, Lewthwaite RA, Pritchard MC, Raphy J, Meecham K, Ratcliffe GS, Suman-Chauhan N, Woodruff GN.
Boden P, et al. Among authors: raphy j.
J Med Chem. 1996 Apr 12;39(8):1664-75. doi: 10.1021/jm950892r.
J Med Chem. 1996.
PMID: 8648606
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Two classes of structurally different antagonists display similar species preference for the human tachykinin neurokinin3 receptor.
Chung FZ, Wu LH, Tian Y, Vartanian MA, Lee H, Bikker J, Humblet C, Pritchard MC, Raphy J, Suman-Chauhan N, et al.
Chung FZ, et al. Among authors: raphy j.
Mol Pharmacol. 1995 Oct;48(4):711-6.
Mol Pharmacol. 1995.
PMID: 7476898
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Utilization of an intramolecular hydrogen bond to increase the CNS penetration of an NK(1) receptor antagonist.
Ashwood VA, Field MJ, Horwell DC, Julien-Larose C, Lewthwaite RA, McCleary S, Pritchard MC, Raphy J, Singh L.
Ashwood VA, et al. Among authors: raphy j.
J Med Chem. 2001 Jul 5;44(14):2276-85. doi: 10.1021/jm010825z.
J Med Chem. 2001.
PMID: 11428921
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Structure-based design in drug discovery--the application of a peptoid drug design strategy for the development of non-peptide neuropeptide receptor ligands.
Pritchard MC, Raphy J, Singh L.
Pritchard MC, et al. Among authors: raphy j.
Expert Opin Investig Drugs. 1997 Apr;6(4):349-65. doi: 10.1517/13543784.6.4.349.
Expert Opin Investig Drugs. 1997.
PMID: 15989604
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Rational design of high affinity tachykinin NK1 receptor antagonists.
Boyle S, Guard S, Higginbottom M, Horwell DC, Howson W, McKnight AT, Martin K, Pritchard MC, O'Toole J, Raphy J, et al.
Boyle S, et al. Among authors: raphy j.
Bioorg Med Chem. 1994 May;2(5):357-70. doi: 10.1016/s0968-0896(00)82192-6.
Bioorg Med Chem. 1994.
PMID: 7922147
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