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Year Number of Results
2004 1
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2008 1
2010 5
2011 1
2012 4
2013 2
2014 2
2015 1
2016 1
2017 1
2018 2
2020 1
2021 1
2023 1
2024 1

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Page 1
Key aspects of modern GPCR drug discovery.
Addis P, Bali U, Baron F, Campbell A, Harborne S, Jagger L, Milne G, Pearce M, Rosethorne EM, Satchell R, Swift D, Young B, Unitt JF. Addis P, et al. Among authors: rosethorne em. SLAS Discov. 2024 Jan;29(1):1-22. doi: 10.1016/j.slasd.2023.08.007. Epub 2023 Aug 23. SLAS Discov. 2024. PMID: 37625784 Free article. Review.
Biased M1-muscarinic-receptor-mutant mice inform the design of next-generation drugs.
Bradley SJ, Molloy C, Valuskova P, Dwomoh L, Scarpa M, Rossi M, Finlayson L, Svensson KA, Chernet E, Barth VN, Gherbi K, Sykes DA, Wilson CA, Mistry R, Sexton PM, Christopoulos A, Mogg AJ, Rosethorne EM, Sakata S, John Challiss RA, Broad LM, Tobin AB. Bradley SJ, et al. Among authors: rosethorne em. Nat Chem Biol. 2020 Mar;16(3):240-249. doi: 10.1038/s41589-019-0453-9. Epub 2020 Feb 20. Nat Chem Biol. 2020. PMID: 32080630 Free article.
Endomorphin-2: a biased agonist at the μ-opioid receptor.
Rivero G, Llorente J, McPherson J, Cooke A, Mundell SJ, McArdle CA, Rosethorne EM, Charlton SJ, Krasel C, Bailey CP, Henderson G, Kelly E. Rivero G, et al. Among authors: rosethorne em. Mol Pharmacol. 2012 Aug;82(2):178-88. doi: 10.1124/mol.112.078659. Epub 2012 May 2. Mol Pharmacol. 2012. PMID: 22553358 Free PMC article.
M3-muscarinic receptor promotes insulin release via receptor phosphorylation/arrestin-dependent activation of protein kinase D1.
Kong KC, Butcher AJ, McWilliams P, Jones D, Wess J, Hamdan FF, Werry T, Rosethorne EM, Charlton SJ, Munson SE, Cragg HA, Smart AD, Tobin AB. Kong KC, et al. Among authors: rosethorne em. Proc Natl Acad Sci U S A. 2010 Dec 7;107(49):21181-6. doi: 10.1073/pnas.1011651107. Epub 2010 Nov 15. Proc Natl Acad Sci U S A. 2010. PMID: 21078968 Free PMC article.
22 results