Similar articles for PMID: 16410408

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1969	1
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1

A novel mechanism of action of methyl-2-cyano-3,12 dioxoolean-1,9 diene-28-oate: direct permeabilization of the inner mitochondrial membrane to inhibit electron transport and induce apoptosis.

Samudio I, Konopleva M, Pelicano H, Huang P, Frolova O, Bornmann W, Ying Y, Evans R, Contractor R, Andreeff M. Samudio I, et al. Mol Pharmacol. 2006 Apr;69(4):1182-93. doi: 10.1124/mol.105.018051. Epub 2006 Jan 12. Mol Pharmacol. 2006. PMID: 16410408

2

The novel triterpenoid CDDO and its derivatives induce apoptosis by disruption of intracellular redox balance.

Ikeda T, Sporn M, Honda T, Gribble GW, Kufe D. Ikeda T, et al. Cancer Res. 2003 Sep 1;63(17):5551-8. Cancer Res. 2003. PMID: 14500394

3

The synthetic triterpenoid 2-cyano-3,12-dioxooleana-1,9-dien-28-oic acid induces caspase-dependent and -independent apoptosis in acute myelogenous leukemia.

Konopleva M, Tsao T, Estrov Z, Lee RM, Wang RY, Jackson CE, McQueen T, Monaco G, Munsell M, Belmont J, Kantarjian H, Sporn MB, Andreeff M. Konopleva M, et al. Cancer Res. 2004 Nov 1;64(21):7927-35. doi: 10.1158/0008-5472.CAN-03-2402. Cancer Res. 2004. PMID: 15520199

4

Apoptotic activity and mechanism of 2-cyano-3,12-dioxoolean-1,9-dien-28-oic-acid and related synthetic triterpenoids in prostate cancer.

Hyer ML, Shi R, Krajewska M, Meyer C, Lebedeva IV, Fisher PB, Reed JC. Hyer ML, et al. Cancer Res. 2008 Apr 15;68(8):2927-33. doi: 10.1158/0008-5472.CAN-07-5759. Cancer Res. 2008. PMID: 18413762

5

The novel triterpenoid 2-cyano-3,12-dioxoolean-1,9-dien-28-oic acid induces apoptosis of human myeloid leukemia cells by a caspase-8-dependent mechanism.

Ito Y, Pandey P, Place A, Sporn MB, Gribble GW, Honda T, Kharbanda S, Kufe D. Ito Y, et al. Cell Growth Differ. 2000 May;11(5):261-7. Cell Growth Differ. 2000. PMID: 10845427

6

Vitamin E protects against the mitochondrial damage caused by cyclosporin A in LLC-PK1 cells.

de Arriba G, de Hornedo JP, Rubio SR, Fernández MC, Martínez SB, Camarero MM, Cid TP. de Arriba G, et al. Toxicol Appl Pharmacol. 2009 Sep 15;239(3):241-50. doi: 10.1016/j.taap.2009.05.028. Epub 2009 Jun 11. Toxicol Appl Pharmacol. 2009. PMID: 19523970

7

Oxidative stress is involved in the permeabilization of the inner membrane of brain mitochondria exposed to hypoxia/reoxygenation and low micromolar Ca2+.

Schild L, Reiser G. Schild L, et al. FEBS J. 2005 Jul;272(14):3593-601. doi: 10.1111/j.1742-4658.2005.04781.x. FEBS J. 2005. PMID: 16008559 Free article.

8

The triterpenoid 2-cyano-3,12-dioxooleana-1,9-dien-28-oic acid and its derivatives elicit human lymphoid cell apoptosis through a novel pathway involving the unregulated mitochondrial permeability transition pore.

Brookes PS, Morse K, Ray D, Tompkins A, Young SM, Hilchey S, Salim S, Konopleva M, Andreeff M, Phipps R, Bernstein SH. Brookes PS, et al. Cancer Res. 2007 Feb 15;67(4):1793-802. doi: 10.1158/0008-5472.CAN-06-2678. Cancer Res. 2007. PMID: 17308122

9

CDDO-Me inhibits proliferation, induces apoptosis, down-regulates Akt, mTOR, NF-kappaB and NF-kappaB-regulated antiapoptotic and proangiogenic proteins in TRAMP prostate cancer cells.

Deeb D, Gao X, Dulchavsky SA, Gautam SC. Deeb D, et al. J Exp Ther Oncol. 2008;7(1):31-9. J Exp Ther Oncol. 2008. PMID: 18472640

10

Inhibition of mitochondrial metabolism by methyl-2-cyano-3,12-dioxooleana-1,9-diene-28-oate induces apoptotic or autophagic cell death in chronic myeloid leukemia cells.

Samudio I, Kurinna S, Ruvolo P, Korchin B, Kantarjian H, Beran M, Dunner K Jr, Kondo S, Andreeff M, Konopleva M. Samudio I, et al. Mol Cancer Ther. 2008 May;7(5):1130-9. doi: 10.1158/1535-7163.MCT-07-0553. Mol Cancer Ther. 2008. PMID: 18483301 Free PMC article.

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