Molecular and cellular analysis of human histamine receptor subtypes

…, D Neumann, S Dove, A Buschauer - Trends in …, 2013 - cell.com
The human histamine receptors hH 1 R and hH 2 R constitute important drug targets, and
hH 3 R and hH 4 R have substantial potential in this area. Considering the species-specificity …

Paradoxical stimulatory effects of the “standard” histamine H4-receptor antagonist JNJ7777120: the H4 receptor joins the club of 7 transmembrane domain receptors …

…, I Brunskole, D Neumann, A Strasser, A Buschauer - Molecular …, 2011 - ASPET
The histamine H 4 receptor (H 4 R) is expressed in several cell types of the immune system
and is assumed to play an important pro-inflammatory role in various diseases, including …

[HTML][HTML] Transport of paclitaxel (Taxol) across the blood-brain barrier in vitro and in vivo

…, H Gschaidmeier, A Buschauer… - The Journal of …, 2002 - Am Soc Clin Investig
Paclitaxel concentrations in the brain are very low after intravenous injection. Since paclitaxel
is excluded from some tumors by p-glycoprotein (p-gp), the same mechanism may prevent …

Species-dependent activities of G-protein-coupled receptor ligands: lessons from histamine receptor orthologs

A Strasser, HJ Wittmann, A Buschauer… - Trends in …, 2013 - cell.com
Histamine is a biogenic amine that exerts its biological effects as a neurotransmitter and local
mediator via four histamine receptor (HR) subtypes (H x Rs) – H 1 R, H 2 R, H 3 R, and H 4 …

Structural basis of small-molecule inhibition of human multidrug transporter ABCG2

…, G Bernhardt, B Koenig, A Buschauer… - Nature structural & …, 2018 - nature.com
ABCG2 is an ATP-binding cassette (ABC) transporter that protects tissues against xenobiotics,
affects the pharmacokinetics of drugs and contributes to multidrug resistance. Although …

Potent and Selective Inhibitors of Breast Cancer Resistance Protein (ABCG2) Derived from the p-Glycoprotein (ABCB1) Modulator Tariquidar

…, G Fricker, B König, A Buschauer - Journal of medicinal …, 2009 - ACS Publications
The efflux pumps ABCB1 (p-gp, MDR1) and ABCG2 (BCRP) are expressed to a high extent
by endothelial cells at the blood−brain barrier (BBB) and other barrier tissues and are …

Structural basis of ligand binding modes at the neuropeptide YY1 receptor

…, J Meiler, Q Zhao, AG Beck-Sickinger, A Buschauer… - Nature, 2018 - nature.com
Neuropeptide Y (NPY) receptors belong to the G-protein-coupled receptor superfamily and
have important roles in food intake, anxiety and cancer biology 1 , 2 . The NPY–Y receptor …

[HTML][HTML] L-Ascorbic acid 6-hexadecanoate, a potent hyaluronidase inhibitor: X-Ray structure and molecular modeling of enzyme-inhibitor complexes

…, S Dove, MJ Jedrzejas, A Buschauer - Journal of Biological …, 2004 - ASBMB
Hyaluronidases are enzymes that degrade hyaluronan, an important component of the
extracellular matrix. The mammalian hyaluronidases are considered to be involved in many (…

Reversible and irreversible labeling and autoradiographic localization of the cerebral histamine H2 receptor using [125I] iodinated probes.

…, J Hirschfeld, A Buschauer… - Proceedings of the …, 1990 - National Acad Sciences
Iodoaminopotentidine (I-APT)--ie, N-[2-(4-amino-3-iodobenzamido)ethyl]-N'-cyano-N''-(3-[3-
(1-piperidinylmethyl)phenoxy]propyl)guanidine--represents one of the most potent H2-…

Effect of the ABCB1 modulators elacridar and tariquidar on the distribution of paclitaxel in nude mice

…, S Fellner, T Spruss, G Bernhardt, A Buschauer - Journal of cancer …, 2008 - Springer
Purpose Previously, we studied the effect of co-administration of paclitaxel with the second
generation ABCB1 (p-gp) modulator valspodar on the intracerebral growth of human U118-…