The concept of intrinsic efficacy has been enshrined in pharmacology for half of a century, yet
recent data have revealed that many ligands can differentially activate signaling pathways …

The Concise Guide to PHARMACOLOGY 2019/20 is the fourth in this series of biennial
publications. The Concise Guide provides concise overviews of the key properties of nearly 1800 …

G protein-coupled receptors (GPCRs) represent the largest family of cell-surface receptors.
These receptors are natural allosteric proteins because agonist-mediated signaling by …

The Concise Guide to PHARMACOLOGY 2021/22 is the fifth in this series of biennial
publications. The Concise Guide provides concise overviews, mostly in tabular format, of the key …

The Concise Guide to PHARMACOLOGY 2017/18 provides concise overviews of the key
properties of nearly 1800 human drug targets with an emphasis on selective pharmacology (…

The recommendations that follow have been updated from the proposals of a Technical
Subcommittee set up by the International Union of Pharmacology Committee on Receptor …

The Concise Guide to PHARMACOLOGY 2021/22 is the fifth in this series of biennial
publications. The Concise Guide provides concise overviews, mostly in tabular format, of the key …

Agonists of seven-transmembrane receptors, also known as G protein-coupled receptors (GPCRs),
do not uniformly activate all cellular signalling pathways linked to a given seven-…

The past decade has witnessed a significant growth in the identification of allosteric modulators
of G protein–coupled receptors (GPCRs), ie, ligands that interact with binding sites that …

We investigated the pharmacology of three novel compounds, Org 27569 (5-chloro-3-ethyl-1H-indole-2-carboxylic
acid [2-(4-piperidin-1-yl-phenyl)-ethyl]-amide), Org 27759 (3-ethyl-5-…