Pharmacology of risperidone (R 64 766), a new antipsychotic with serotonin-S2 and dopamine-D2 antagonistic properties.

…, F Awouters, KH Schellekens, AA Megens… - Journal of pharmacology …, 1988 - ASPET
Comparative studies of the benzisoxazole derivative risperidone (R 64 766) were made
with ritanserin, a selective centrally acting serotonin-S2 antagonist and with haloperidol, a …

Risperidone: a novel antipsychotic with balanced serotonin-dopamine antagonism, receptor occupancy profile, and pharmacologic activity.

JE Leysen, PM Janssen, AA Megens… - The Journal of clinical …, 1994 - europepmc.org
The interaction of risperidone, 9-hydroxyrisperidone (the principal active metabolite), and
clozapine with neurotransmitter receptors was investigated in vitro using animal brain tissue …

Discovery of a New Series of Centrally Active Tricyclic Isoxazoles Combining Serotonin (5-HT) Reuptake Inhibition with α2-Adrenoceptor Blocking Activity

…, I Lenaerts, S Martínez, AA Megens… - Journal of medicinal …, 2005 - ACS Publications
The synthesis and pharmacology of a new series of 3-piperazinylmethyl-3a,4-dihydro-3H-[1]benzopyrano[4,3-c]isoxazoles
that combine central serotonin (5-HT) reuptake inhibition with …

Tricyclic isoxazolines: Identification of R226161 as a potential new antidepressant that combines potent serotonin reuptake inhibition and α2-adrenoceptor …

…, X Langlois, I Lenaerts, S Martínez, AA Megens… - Bioorganic & medicinal …, 2007 - Elsevier
In previous articles we have described the discovery of a new series of tricyclic isoxazolines
combining central serotonin (5-HT) reuptake inhibition with α 2 -adrenoceptor antagonistic …

General pharmacology of the four gastrointestinal motility stimulants bethanechol, metoclopramide, trimebutine, and cisapride.

AA Megens, FH Awouters, CJ Niemegeers - Arzneimittel-forschung, 1991 - europepmc.org
The pharmacological profile of bethanechol (CAS 674-38-4), metoclopramide (CAS 364-62-5),
trimebutine (CAS 39133-31-8) and cisapride (CAS 81098-60-4) was studied in a series …

Synthesis of 3a, 4-dihydro-3H-[1] benzopyrano [4, 3-c] isoxazoles, displaying combined 5-HT uptake inhibiting and α2-adrenoceptor antagonistic activities: a novel …

…, MH Bakker, I Biesmans, LI Heylen, AA Megens - Bioorganic & Medicinal …, 2003 - Elsevier
The synthesis of a series of novel 3-piperazinylmethyl-3a,4-dihydro-3H-[1]benzopyrano[4,3-c]isoxazoles
as novel dual 5-HT reuptake inhibitors and α 2 -adrenoceptor antagonists is …

Synthesis of 7-amino-3a, 4-dihydro-3H-[1] benzopyrano [4, 3-c] isoxazole derivatives displaying combined α2-adrenoceptor antagonistic and 5-HT reuptake inhibiting …

…, AI De Lucas, L Iturrino, I Biesmans, AA Megens - Bioorganic & medicinal …, 2006 - Elsevier
Following a program searching for dual 5-HT reuptake inhibitors and α 2 -adrenoceptor
antagonists started at Johnson & Johnson Pharmaceutical Research & Development, we now …

[PDF][PDF] Behavioral disinhibition and depression in amphetaminized rats: a comparison of risperidone, ocaperidone and haloperidol.

AA Megens, CJ Niemegeers, FH Awouters - Journal of Pharmacology and …, 1992 - Citeseer
The mixed serotonin-2/dopamine-D2 antagonists nspendone and ocaperidone were compared
with the specific D2 antagonist halopendol for their ability to antagonize amphetamine(1 …

Functional interaction between serotonin-S2 and dopamine-D2 neurotransmission as revealed by selective antagonism of hyper-reactivity to tryptamine and …

F Awouters, CJ Niemegeers, AA Megens… - Journal of Pharmacology …, 1990 - ASPET
The functional significance of the interaction between serotonergic and dopaminergic
neurotransmission is still uncertain. To document this interaction further, specific behavioral …

Synthesis of 3a, 4-dihydro-3H-[1] benzopyrano [4, 3-c] isoxazoles, displaying combined 5-HT uptake inhibiting and α2-adrenoceptor antagonistic activities. Part 2 …

…, MH Bakker, I Biesmans, LI Heylen, AA Megens - Bioorganic & medicinal …, 2004 - Elsevier
In our previous paper we have described the synthesis of a series of 3-piperazinylmethyl-3a,4-dihydro-3H-[1]benzopyrano[4,3-c]isoxazoles,
as novel dual 5-HT reuptake inhibitors and …