The seven transmembrane α-helices of G protein-coupled receptors (GPCRs) are the hallmark
of this superfamily. Intrahelical interactions are critical to receptor assembly and, for the …

The classical cannabinoid agonist HU210, a structural analog of (−)-Δ 9 -tetrahydrocannabinol,
binds to brain cannabinoid (CB1) receptors and activates signal transduction pathways. …

The cannabinoid receptor one (CB1) is a class A G-protein-coupled receptor thought to bind
ligands primarily within its helical bundle. Evidence suggests, however, that the …

Synonymous nucleotide variation is increasingly recognized as a factor than can affect
protein expression, but the underlying mechanisms are incompletely understood. Here, we …

SR141716A binds selectively to the brain cannabinoid (CB1) receptor and exhibits a potent
inverse agonist/antagonist activity. Although SR141716A, also known as rimonabant, has …

Friedreich's Ataxia (FA) is an autosomal recessive disorder with an incidence of 1 in 50,000
in Caucasians. Most cases are caused by a biallelic GAA expansion in the first intron of the …

… Interestingly, the tryptophan residue, corresponding to W504 of mFZD 4 , was shown to
interact with the artificial lipid bilayer suggesting it could mimic the role of a C-tail palmitoyal …

Dilated Cardiomyopathy (DCM) is one of the main causes of sudden cardiac death and
heart failure and is the leading indication for cardiac transplantation worldwide. Mutations in …

Familial exudative vitreoretinopathy (FEVR) is a disease state characterized by aberrant retinal
angiogenesis. Norrin-induced activation of Frizzled-4 (Fz4) has a major role in regulating …

… Here we describe the impact of an N-terminal myc fusion tag, a C-terminal myc fusion tag
and a PCR-induced double mutation not found in population sequence databases on the WT …