User profiles for A. E. Stacy
Alexandra StacyPhD, University of Sydney Verified email at my.nd.edu.au Cited by 904 |
[HTML][HTML] Clinical development of targeted and immune based anti-cancer therapies
NA Seebacher, AE Stacy, GM Porter… - Journal of Experimental & …, 2019 - Springer
Cancer is currently the second leading cause of death globally and is expected to be responsible
for approximately 9.6 million deaths in 2018. With an unprecedented understanding of …
for approximately 9.6 million deaths in 2018. With an unprecedented understanding of …
Molecular pharmacology of ABCG2 and its role in chemoresistance
The ATP-binding cassette, subfamily G, isoform 2 protein (ABCG2) is an important member
of the ABC transporter superfamily, which has been suggested to be involved in multidrug …
of the ABC transporter superfamily, which has been suggested to be involved in multidrug …
Zinc (II)–thiosemicarbazone complexes are localized to the lysosomal compartment where they transmetallate with copper ions to induce cytotoxicity
AE Stacy, D Palanimuthu, PV Bernhardt… - Journal of medicinal …, 2016 - ACS Publications
As the di-2-pyridylketone thiosemicarbazone (DpT) and 2-acetylpyridine thiosemicarbazone
(ApT) series show potent antitumor activity in vitro and in vivo, we synthesized their …
(ApT) series show potent antitumor activity in vitro and in vivo, we synthesized their …
Structure–activity relationships of di-2-pyridylketone, 2-benzoylpyridine, and 2-acetylpyridine thiosemicarbazones for overcoming Pgp-mediated drug resistance
AE Stacy, D Palanimuthu, PV Bernhardt… - Journal of Medicinal …, 2016 - ACS Publications
Multidrug resistance (MDR) mediated by P-glycoprotein (Pgp) represents a significant
impediment to successful cancer treatment. The compound, di-2-pyridylketone 4,4-dimethyl-3-…
impediment to successful cancer treatment. The compound, di-2-pyridylketone 4,4-dimethyl-3-…
[HTML][HTML] Tumour microenvironment stress promotes the development of drug resistance
Multi-drug resistance (MDR) is a leading cause of cancer-related death, and it continues to
be a major barrier to cancer treatment. The tumour microenvironment (TME) has proven to …
be a major barrier to cancer treatment. The tumour microenvironment (TME) has proven to …
Evaluation of a pilot vancomycin precision dosing advisory service on target exposure attainment using an interrupted time series analysis
This study evaluated the ability of a pilot therapeutic drug monitoring (TDM) Advisory Service
to facilitate vancomycin therapeutic target attainment within a real‐world clinical setting. …
to facilitate vancomycin therapeutic target attainment within a real‐world clinical setting. …
Blood, dose recommendation reports and phone calls: Experiences of a therapeutic drug monitoring advisory service for vancomycin
Dose‐prediction software is recommended to enable area under the curve over 24 h (AUC
24 )‐guided dosing of the antibiotic vancomycin. However, uncertainty remains about how …
24 )‐guided dosing of the antibiotic vancomycin. However, uncertainty remains about how …
A low-footprint, fluorescence-based bacterial time-kill assay for estimating dose-dependent cell death dynamics
Dose-response curves that describe the relationship between antibiotic dose and growth rate
in bacteria are commonly measured with optical density (OD) based assays. While being …
in bacteria are commonly measured with optical density (OD) based assays. While being …
Thiosemicarbazones Target Multiple Resistance Pathways in Cancer
AE Stacy - 2016 - ses.library.usyd.edu.au
Multidrug resistance (MDR) is a significant obstacle in the successful treatment of cancer.
To date, no therapies that target MDR have reached the clinic. Our thiosemicarbazone …
To date, no therapies that target MDR have reached the clinic. Our thiosemicarbazone …
Enhanced convective heat transfer in nongas generating nanoparticle thermites
SW Dean, ML Pantoya, AE Gash, SC Stacy… - 2010 - asmedigitalcollection.asme.org
Flame propagation and peak pressure measurements were taken of two nanoscaled
thermites using aluminum (Al) fuel and copper oxide (CuO) or nickel oxide (NiO) oxidizers in a …
thermites using aluminum (Al) fuel and copper oxide (CuO) or nickel oxide (NiO) oxidizers in a …