User profiles for A. E. Stacy

Alexandra Stacy

PhD, University of Sydney
Verified email at my.nd.edu.au
Cited by 904

[HTML][HTML] Clinical development of targeted and immune based anti-cancer therapies

NA Seebacher, AE Stacy, GM Porter… - Journal of Experimental & …, 2019 - Springer
Cancer is currently the second leading cause of death globally and is expected to be responsible
for approximately 9.6 million deaths in 2018. With an unprecedented understanding of …

Molecular pharmacology of ABCG2 and its role in chemoresistance

AE Stacy, PJ Jansson, DR Richardson - Molecular pharmacology, 2013 - ASPET
The ATP-binding cassette, subfamily G, isoform 2 protein (ABCG2) is an important member
of the ABC transporter superfamily, which has been suggested to be involved in multidrug …

Zinc (II)–thiosemicarbazone complexes are localized to the lysosomal compartment where they transmetallate with copper ions to induce cytotoxicity

AE Stacy, D Palanimuthu, PV Bernhardt… - Journal of medicinal …, 2016 - ACS Publications
As the di-2-pyridylketone thiosemicarbazone (DpT) and 2-acetylpyridine thiosemicarbazone
(ApT) series show potent antitumor activity in vitro and in vivo, we synthesized their …

Structure–activity relationships of di-2-pyridylketone, 2-benzoylpyridine, and 2-acetylpyridine thiosemicarbazones for overcoming Pgp-mediated drug resistance

AE Stacy, D Palanimuthu, PV Bernhardt… - Journal of Medicinal …, 2016 - ACS Publications
Multidrug resistance (MDR) mediated by P-glycoprotein (Pgp) represents a significant
impediment to successful cancer treatment. The compound, di-2-pyridylketone 4,4-dimethyl-3-…

[HTML][HTML] Tumour microenvironment stress promotes the development of drug resistance

NA Seebacher, M Krchniakova, AE Stacy, J Skoda… - Antioxidants, 2021 - mdpi.com
Multi-drug resistance (MDR) is a leading cause of cancer-related death, and it continues to
be a major barrier to cancer treatment. The tumour microenvironment (TME) has proven to …

Evaluation of a pilot vancomycin precision dosing advisory service on target exposure attainment using an interrupted time series analysis

…, JE Carland, SE Reuter, AE Stacy… - Clinical …, 2021 - Wiley Online Library
This study evaluated the ability of a pilot therapeutic drug monitoring (TDM) Advisory Service
to facilitate vancomycin therapeutic target attainment within a real‐world clinical setting. …

Blood, dose recommendation reports and phone calls: Experiences of a therapeutic drug monitoring advisory service for vancomycin

JE Carland, AE Stacy, AL Schaffer… - British Journal of …, 2023 - Wiley Online Library
Dose‐prediction software is recommended to enable area under the curve over 24 h (AUC
24 )‐guided dosing of the antibiotic vancomycin. However, uncertainty remains about how …

A low-footprint, fluorescence-based bacterial time-kill assay for estimating dose-dependent cell death dynamics

ES King, AE Stacy, JG Scott - bioRxiv, 2024 - biorxiv.org
Dose-response curves that describe the relationship between antibiotic dose and growth rate
in bacteria are commonly measured with optical density (OD) based assays. While being …

Thiosemicarbazones Target Multiple Resistance Pathways in Cancer

AE Stacy - 2016 - ses.library.usyd.edu.au
Multidrug resistance (MDR) is a significant obstacle in the successful treatment of cancer.
To date, no therapies that target MDR have reached the clinic. Our thiosemicarbazone …

Enhanced convective heat transfer in nongas generating nanoparticle thermites

SW Dean, ML Pantoya, AE Gash, SC Stacy… - 2010 - asmedigitalcollection.asme.org
Flame propagation and peak pressure measurements were taken of two nanoscaled
thermites using aluminum (Al) fuel and copper oxide (CuO) or nickel oxide (NiO) oxidizers in a …