Opioid analgesics: chemistry and receptors

AF Casy, RT Parfitt - 2013 - books.google.com
The rapidly burgeoning research of the past two decades on agonist-antagonist analgesics
and opioid receptors makes this exhaustive review of opioid anal gesics particularly relevant …

[BOOK][B] The benzodiazepine story

AF Casy, PF D'Arcy, EM Scott, HP Kuemmerle… - 1978 - Springer
For 10 years Valium ® (2) has been the most frequently prescribed drug. It is a safe, potent
anxiolytic with pronounced muscle relaxant properties, and is the best known tranquilizer of …

Synthetic analgesics: stereochemical considerations

AH Beckett, AF Casy - Journal of Pharmacy and Pharmacology, 1954 - cir.nii.ac.jp
< jats: title> Summary < jats: p> The evidence is presented for the probability of the activity
exhibited by analgesics and their antagonists being due to their association with a specific …

Sedation and histamine H1-receptor antagonism: studies in man with the enantiomers of chlorpheniramine and dimethindene.

…, CR Ganellin, PM Greengrass, AF Casy… - British journal of …, 1991 - ncbi.nlm.nih.gov
The effects of 10 mg (+)-and (-)-chlorpheniramine and 5 mg (+)-and (-)-dimethindene on
daytime sleep latencies, digit symbol substitution and subjective assessments of mood and well-…

Chiral discrimination by NMR spectroscopy

AF Casy - TrAC Trends in Analytical Chemistry, 1993 - Elsevier
The techniques for chiral recognition in NMR are reviewed with reference to applications
primarily in the life sciences. A number of strategies for chiral discrimination are discussed in …

Stereochemical studies of chiral h‐1 antagonists of histamine: The resolution, chiral analysis, and biological evaluation of four antipodal pairs

AF Casy, AF Drake, CR Ganellin, AD Mercer… - Chirality, 1992 - Wiley Online Library
The resolution of the H‐1 antihistamines chloropheniramine, dimethindene, carbinoxamine,
and mebrophenhydramine is described. The optical purity of antipodal products is …

Application of cyclodextrins to chiral analysis by 1H NMR spectroscopy

AF Casy, AD Mercer - Magnetic resonance in chemistry, 1988 - Wiley Online Library
The influence of inclusion complex formation between cyclodextrins (chiefly the β‐polymer)
and a variety of chiral antihistaminic and analgesic agents on the 1 H NMR features of both …

The biotransformation of methadone in man: synthesis and identification of a major metabolite

AH Beckett, JF Taylor, AF Casy… - Journal of Pharmacy …, 1968 - academic.oup.com
After administration of methadone to man, only two basic urinary excretion products were
detected, these were unchanged drug and 2-ethyl-1, 5-dimethyl-3, 3-diphenyl-1-pyrroline. The …

[BOOK][B] The steric factor in medicinal chemistry: dissymmetric probes of pharmacological receptors

AF Casy - 2013 - books.google.com
Casy to bring to these pages a clear and comprehensive view of medicinal stereochemistry,
a discipline in which he has been active and successful for many years both as a teacher …

5 Analgesics and their Antagonists: Biochemical Aspects and Structure-Activity Relationships

AH Beckett, AF Casy - Progress in medicinal chemistry, 1965 - Elsevier
Publisher Summary This chapter discusses the many aspects of analgesics: (a) estimation
of analgesics in biological media; (b) absorption, distribution and excretion of analgesics; (c) …