Ionotropic and metabotropic mechanisms in chemoreception:'chance or design'?

AF Silbering, R Benton - EMBO reports, 2010 - embopress.org
Chemosensory receptors convert an enormous diversity of chemical signals from the external
world into a common language of electrical activity in the brain. Mammals and insects use …

Complementary function and integrated wiring of the evolutionarily distinct Drosophila olfactory subsystems

AF Silbering, R Rytz, Y Grosjean, L Abuin… - Journal of …, 2011 - Soc Neuroscience
To sense myriad environmental odors, animals have evolved multiple, large families of
divergent olfactory receptors. How and why distinct receptor repertoires and their associated …

Distinct combinations of variant ionotropic glutamate receptors mediate thermosensation and hygrosensation in Drosophila

ZA Knecht, AF Silbering, L Ni, M Klein, G Budelli, R Bell… - Elife, 2016 - elifesciences.org
10.7554/eLife.17879.001 Ionotropic Receptors (IRs) are a large subfamily of variant
ionotropic glutamate receptors present across Protostomia. While these receptors are most …

Processing of odor mixtures in the Drosophila antennal lobe reveals both global inhibition and glomerulus-specific interactions

AF Silbering, CG Galizia - Journal of Neuroscience, 2007 - Soc Neuroscience
To understand how odor information is represented and processed in the antennal lobe (AL)
of Drosophila melanogaster, we have optically recorded glomerular calcium responses to …

[PDF][PDF] Evolution of acid-sensing olfactory circuits in drosophilids

…, R Rytz, S Cruchet, B Bargeton, L Abuin, AF Silbering… - Neuron, 2017 - cell.com
Animals adapt their behaviors to specific ecological niches, but the genetic and cellular basis
of nervous system evolution is poorly understood. We have compared the olfactory circuits …

Ionotropic Receptor-dependent moist and dry cells control hygrosensation in Drosophila

ZA Knecht, AF Silbering, J Cruz, L Yang, V Croset… - Elife, 2017 - elifesciences.org
10.7554/eLife.26654.001 Insects use hygrosensation (humidity sensing) to avoid desiccation
and, in vectors such as mosquitoes, to locate vertebrate hosts. Sensory neurons activated …

Olfactory receptor and circuit evolution promote host specialization

TO Auer, MA Khallaf, AF Silbering, G Zappia, K Ellis… - Nature, 2020 - nature.com
The evolution of animal behaviour is poorly understood 1 , 2 . Despite numerous correlations
between interspecific divergence in behaviour and nervous system structure and function, …

Olfactory information processing in the Drosophila antennal lobe: anything goes?

AF Silbering, R Okada, K Ito… - Journal of Neuroscience, 2008 - Soc Neuroscience
When an animal smells an odor, olfactory sensory neurons generate an activity pattern across
olfactory glomeruli of the first sensory neuropil, the insect antennal lobe or the vertebrate …

[HTML][HTML] An expression atlas of variant ionotropic glutamate receptors identifies a molecular basis of carbonation sensing

JA Sánchez-Alcañiz, AF Silbering, V Croset… - Nature …, 2018 - nature.com
Through analysis of the Drosophila ionotropic receptors (IRs), a family of variant ionotropic
glutamate receptors, we reveal that most IRs are expressed in peripheral neuron populations …

[PDF][PDF] Ionotropic receptors specify the morphogenesis of phasic sensors controlling rapid thermal preference in Drosophila

…, ZA Knecht, EC Chang, B Kaminski, AF Silbering… - Neuron, 2019 - cell.com
Thermosensation is critical for avoiding thermal extremes and regulating body temperature.
While thermosensors activated by noxious temperatures respond to hot or cold, many …