17β-Estradiol (E 2 ) rapidly (<20 min) attenuates the ability of μ-opioids to hyperpolarize
guinea pig hypothalamic neurons. We have used intracellular recordings from female guinea …

17β-Estradiol (E 2 ) rapidly (<20 min) attenuates the ability of μ-opioids to hyperpolarize
guinea pig hypothalamic (β-endorphin) neurons. In the current study, we used intracellular …

Control of the HPG axis involves a rapid (30 min) inhibition of LH (GnRH) release by E2. The
time course of this effect is faster than expected for a purely transcriptional mechanism of …

OBJECTIVE: To share our experience on clinical presentation and management of patients
diagnosed with Hashimoto's Encephalopathy (HE) at Vanderbilt Medical Center between …

Here we report on the progress we have made in elucidating the mechanisms through which
estrogen alters synaptic responses in hypothalamic neurons. We examined the modulation …

Adenosine-to-inosine (A-to-I) editing of RNA transcripts is an increasingly recognized cellular
strategy to modulate the function of proteins involved in neuronal excitability. We have …

Up‐regulation of the GABA A receptor α4 subunit subtype has been consistently shown in
multiple animal models of chronic epilepsy. This isoform is expressed in both thalamus and …

We performed next generation sequencing on 1696 patients with epilepsy and intellectual
disability using a gene panel with 480 epilepsy-related genes including all GABA A receptor …

GABA is a predominant neurotransmitter in the hypothalamus and an important regulator of
hypothalamic function. To elucidate the cellular basis for GABAergic action in this region, we …

The mu-opioid agonist DAMGO (Tyr-D-Ala-Gly-MePhe-Gly-ol) hyperpolarizes the majority of
arcuate hypothalamic (ARC) neurons by opening an inwardly rectifying potassium …