Protein Kinase B/Akt Phosphorylates and Inhibits the Cardiac Na+/H+ Exchanger NHE1
AK Snabaitis, F Cuello, M Avkiran - Circulation research, 2008 - Am Heart Assoc
Sarcolemmal Na + /H + exchanger (NHE) activity is mediated by NHE isoform 1 (NHE1),
which is subject to regulation by protein kinases. Our objectives were to determine whether …
which is subject to regulation by protein kinases. Our objectives were to determine whether …
[HTML][HTML] Stimulation of the plasma membrane Na+/H+ exchanger NHE1 by sustained intracellular acidosis: evidence for a novel mechanism mediated by the ERK …
RS Haworth, C McCann, AK Snabaitis… - Journal of Biological …, 2003 - ASBMB
Activity of the Na + /H + exchanger (NHE) isoform 1 (NHE1) is increased by intracellular
acidosis through the interaction of intracellular H + with an allosteric modifier site in the transport …
acidosis through the interaction of intracellular H + with an allosteric modifier site in the transport …
Roles of Mitogen-Activated Protein Kinases and Protein Kinase C in α1A-Adrenoceptor–Mediated Stimulation of the Sarcolemmal Na+-H+ Exchanger
AK Snabaitis, H Yokoyama, M Avkiran - Circulation research, 2000 - Am Heart Assoc
Activation of the sarcolemmal Na + -H + exchanger (NHE) has been implicated as a mechanism
of inotropic, arrhythmogenic, antiacidotic, and hypertrophic effects of α 1 -adrenoceptor (…
of inotropic, arrhythmogenic, antiacidotic, and hypertrophic effects of α 1 -adrenoceptor (…
Ca2+/calmodulin-dependent protein kinase II contributes to intracellular pH recovery from acidosis via Na+/H+ exchanger activation
…, N Lezcano, AK Snabaitis… - Journal of Molecular and …, 2010 - Elsevier
The Na + /H + exchanger (NHE-1) plays a key role in pH i recovery from acidosis and is
regulated by pH i and the ERK1/2-dependent phosphorylation pathway. Since acidosis …
regulated by pH i and the ERK1/2-dependent phosphorylation pathway. Since acidosis …
Inhibition of the Na+/H+ exchanger attenuates the deterioration of ventricular function during pacing-induced heart failure in rabbits
S Aker, AK Snabaitis, I Konietzka… - Cardiovascular …, 2004 - academic.oup.com
Aims: Inhibition of the Na + /H + -exchanger (NHE) preserves myocardial morphology and
function in rat and mouse models of hypertrophy and failure. The mechanism(s) involved in …
function in rat and mouse models of hypertrophy and failure. The mechanism(s) involved in …
Enzyme inhibition as a potential therapeutic strategy to treat COVID-19 infection
L Paulsson-Habegger, AK Snabaitis… - Bioorganic & Medicinal …, 2021 - Elsevier
With the emergence of the third infectious and virulent coronavirus within the past two decades,
it has become increasingly important to understand how the virus causes infection. This …
it has become increasingly important to understand how the virus causes infection. This …
Regulation of the extracellular signal-regulated kinase pathway in adult myocardium: differential roles of Gq/11, Gi and G12/13 proteins in signalling by α1-adrenergic …
AK Snabaitis, A Muntendorf, T Wieland, M Avkiran - Cellular signalling, 2005 - Elsevier
Using adenoviruses encoding RGS2, RGS4 and Lsc (regulator of G protein signalling (RGS)
domain of p115 RhoGEF), we investigated the contributions of G q/11 , G i and G 12/13 …
domain of p115 RhoGEF), we investigated the contributions of G q/11 , G i and G 12/13 …
Evidence for direct regulation of myocardial Na+/H+ exchanger isoform 1 phosphorylation and activity by 90-kDa ribosomal S6 kinase (RSK): effects of the novel and …
Multiple stimuli of physiological and pathophysiological significance, including α 1 -adrenoceptor
agonists, stimulate the cardiac sarcolemmal Na + /H + exchanger isoform 1 (NHE1) …
agonists, stimulate the cardiac sarcolemmal Na + /H + exchanger isoform 1 (NHE1) …
[HTML][HTML] A novel role for protein phosphatase 2A in receptor-mediated regulation of the cardiac sarcolemmal Na+/H+ exchanger NHE1
AK Snabaitis, R D'Mello, S Dashnyam… - Journal of biological …, 2006 - ASBMB
G q protein-coupled receptor stimulation increases sarcolemmal Na + /H + exchanger (NHE1)
activity in cardiac myocytes by an ERK/RSK-dependent mechanism, most likely via RSK-…
activity in cardiac myocytes by an ERK/RSK-dependent mechanism, most likely via RSK-…
Regulation of sarcolemmal Na+/H+ exchange by hydrogen peroxide in adult rat ventricular myocytes
AK Snabaitis, DJ Hearse, M Avkiran - Cardiovascular research, 2002 - academic.oup.com
Objective: To characterise the effects of exogenous H 2 O 2 on sarcolemmal Na + /H +
exchanger (NHE) activity and determine the roles of extracellular signal-regulated kinase (ERK), …
exchanger (NHE) activity and determine the roles of extracellular signal-regulated kinase (ERK), …