Ubiquitin‐mediated proteolysis: biological regulation via destruction

A Ciechanover, A Orian, AL Schwartz - Bioessays, 2000 - Wiley Online Library
The ubiquitin proteolytic system plays an important role in a broad array of basic cellular
processes. Among these are regulation of cell cycle, modulation of the immune and …

Targeting proteins for destruction by the ubiquitin system: implications for human pathobiology

AL Schwartz, A Ciechanover - Annual review of pharmacology …, 2009 - annualreviews.org
Cellular proteins are in a dynamic state maintained by synthesis and degradation. The
ubiquitin proteolytic pathway is responsible for the degradation of the bulk of cellular proteins …

The ubiquitin‐mediated proteolytic pathway: Mode of action and clinical implications

…, A Orian, AL Schwartz - Journal of cellular …, 2000 - Wiley Online Library
Proteolysis via the ubiquitin system plays important roles in a variety of basic cellular processes.
Among these are regulation of cell cycle and division, modulation of the immune and …

Intracellular site of asialoglycoprotein receptor-ligand uncoupling: double-label immunoelectron microscopy during receptor-mediated endocytosis

…, JW Slot, GJAM Strous, HF Lodish, AL Schwartz - Cell, 1983 - cell.com
In rats infused with asialoglycoprotein for 60 min, receptor-mediated endocytosis of the
ligand occurred exclusively in hepatic parenchymal cells. We have used double-label …

Kinetics of internalization and recycling of transferrin and the transferrin receptor in a human hepatoma cell line. Effect of lysosomotropic agents.

A Ciechanover, AL Schwartz, A Dautry-Varsat… - Journal of Biological …, 1983 - Elsevier
… developed by Wiley and Cunningham (21) for epidermal growth factor receptor and by
Schwartz et al. (5) for the asialoglycoprotein receptor. That, because the transferrin receptor can …

The ubiquitin-proteasome pathway: the complexity and myriad functions of proteins death

A Ciechanover, AL Schwartz - Proceedings of the National …, 1998 - National Acad Sciences
Our perception of intracellular protein degradation has changed dramatically during the
recent decade. From a scavenger, unregulated, and nonspecific ‘‘end point’’process, it has …

Modulators of cyclic AMP metabolism induce syncytiotrophoblast formation in vitro

B Wice, D Menton, H Geuze, AL Schwartz - Experimental cell research, 1990 - Elsevier
During placental development cytotrophoblast stem cells fuse to form the syncytiotrophoblast,
a multinucleate cytoplasm with a brush border in contact with the maternal blood. …

Estimated prevalence and clinical manifestations of UBA1 variants associated with VEXAS syndrome in a clinical population

…, A Cantor, JS Haley, A Cook, W Hill, AL Schwartz… - Jama, 2023 - jamanetwork.com
Importance VEXAS (vacuoles, E1-ubiquitin-activating enzyme, X-linked, autoinflammatory,
somatic) syndrome is a disease with rheumatologic and hematologic features caused by …

Low density lipoprotein receptor-related protein mediates apolipoprotein E-dependent neurite outgrowth in a central nervous system-derived neuronal cell line.

…, RW Mahley, G Bu, AL Schwartz - Proceedings of the …, 1995 - National Acad Sciences
The epsilon 4 allele of apolipoprotein E (apoE) is a major risk factor for Alzheimer disease,
suggesting that apoE may directly influence neurons in the aging brain. Recent data suggest …

[HTML][HTML] Ubiquitin-dependent degradation of certain protein substrates in vitro requires the molecular chaperone Hsc70

…, A Mayer, N Blumenfeld, A Laszlo, AL Schwartz… - Journal of Biological …, 1997 - ASBMB
Degradation of a protein via the ubiquitin system involves two discrete steps, signaling by
covalent conjugation of multiple moieties of ubiquitin and degradation of the tagged substrate. …