Traditionally, glutamate transporters have been viewed as membrane proteins that harness
the electrochemical gradient to slowly transport glutamate from the extracellular space into …

Arc/Arg3.1 is an effector immediate-early gene implicated in the consolidation of memories.
Although cloned a decade ago, the physiological role of Arc/Arg3.1 in the brain has …

Exome and targeted sequencing have revolutionized clinical diagnosis. This has been
particularly striking in epilepsy and neurodevelopmental disorders, for which new genes or new …

… Tzingounis, personal communication) was adapted to simulate the kinetics of GLT-1-mediated
transporter currents (Fig. 2A). This model is based on an alternating access scheme (…

Benign familial neonatal convulsion (BNFC) is a neurological disorder caused by mutations
in the potassium channel genes KCNQ2 and KCNQ3, which are thought to contribute to the …

Mutations in KCNQ2 and KCNQ3 voltage-gated potassium channels lead to neonatal epilepsy
as a consequence of their key role in regulating neuronal excitability. Previous studies in …

… Kcnq3 knock-out mice survive into adulthood (Tzingounis and Nicoll, 2008). In the case of
… Karen Menuz, Jacques Wadiche, and Anna Lisa Lucido, and members of the Tzingounis …

In the brain, calcium influx following a train of action potentials activates potassium channels
that mediate a slow afterhyperpolarization current (I sAHP ). The key steps between calcium …

Voltage-gated Kv7 (KCNQ) channels are voltage-dependent potassium channels that are
activated at resting membrane potentials and therefore provide a powerful brake on neuronal …

Super-resolution microscopy recently revealed that, unlike the soma and dendrites, the axon
membrane skeleton is structured as a series of actin rings connected by spectrin filaments …