Brain tumors represent a heterogeneous group of neoplasms characterized by a high
degree of aggressiveness and a poor prognosis. Despite recent therapeutic advances, the …

A scalable method for the assembly of oriented bacterial cellulose (BC) films is presented
based on using wrinkled thin silicone substrates of meter-square size as templates during …

The vascular smooth muscle (VSM) of resistance blood vessels is a target of intrinsic
autoregulatory responses to increased intraluminal pressure, the myogenic response. In the brain, …

A novel inhibitor of zipper-interacting protein kinase (ZIPK) was used to examine the
involvement of ZIPK in the regulation of smooth muscle contraction. Pretreatment of de-…

Background: Neuroblastoma (NB) is one of the most aggressive and common solid tumors
in pediatrics. Development of effective new therapeutics for NB is in progress to help reduce …

The selectivity of (4Z)-2-(4-chloro-3-nitrophenyl)-4-(pyridin-3-ylmethylidene)-1,3-oxazol-5-one
(DI) for zipper-interacting protein kinase (ZIPK) was previously described by in silico …

Enhancer of zeste homolog 2 (EZH2) is a histone methyltransferase and a catalytic subunit
of the polycomb repressive complex 2 (PRC2) that catalyzes the mono-, di-, and tri-…

Background Rhabdomyosarcoma (RMS) is the most common soft-tissue sarcoma in children.
Pathogenesis of RMS is associated with aggressive growth pattern and increased risk of …

Receptor tyrosine kinases (RTKs) are recognized as targets of precision medicine in human
cancer upon their gene amplification or constitutive activation, resulting in increased …

Apolipoprotein E (apoE), a polymorphic plasma protein, plays a pivotal role in lipid transportation.
The human apoE gene possesses three major alleles (ε2, ε3, and ε4), which differ by …