Many cancers, including breast cancer, have demonstrated prognosis and support advantages
thanks to the discovery of targeted therapies. The advent of these new approaches …

The nature of the signaling pathway(s) which initiate drug‐triggered apoptosis remains
largely unknown and is of fundamental importance in understanding cell death induced by …

Post-translational modifications of proteins can regulate the balance between survival and
cell death signals. It is increasingly recognized that nitric oxide (NO) and reactive oxygen …

Most chemotherapeutic drugs can induce tumor cell death by apoptosis. Analysis of the
molecular mechanisms that regulate apoptosis has indicated that anticancer agents …

We investigated the capacity of dietary (−)-epicatechin (EC) to mitigate insulin resistance
through the modulation of redox-regulated mechanisms in a rat model of metabolic syndrome. …

Background & Aims Fas belongs to the family of tumor necrosis factor receptors which induce
apoptosis. Many cancer cells express Fas but do not undergo Fas-mediated apoptosis. …

Thethreemainstaysforcancertreatmentincludesurgicalremovaloftumors, radiationtherapy and
chemotherapy, which have led to improved patient survival for certain types of cancer, but …

Elevated blood branched-chain amino acids (BCAA) are often associated with insulin
resistance and type 2 diabetes, which might result from a reduced cellular utilization and/or …

Anthracyclines such as daunorubicin (DNR) generate radical oxygen species (ROS), which
account, at least in part, for their cytotoxic effect. We observed that early ceramide generation …

We have previously demonstrated that daunorubicin (DNR) induces apoptosis in some
leukemic myeloid cell lines. We investigated a potential protective role for Bcl-2 in apoptosis …