User profiles for A. Elorza

Alvaro A. Elorza

Full Professor, Institute of Biomedical Sciences, Universidad Andres Bello
Verified email at unab.cl
Cited by 6389

Molecularly imprinted polymers: synthesis and characterisation

PAG Cormack, AZ Elorza - Journal of chromatography B, 2004 - Elsevier
This short review aims to present, in clear English, a summary of the principal synthetic
considerations pertaining to good practice in the polymerisation aspects of molecular imprinting, …

[HTML][HTML] Role of copper on mitochondrial function and metabolism

LM Ruiz, A Libedinsky, AA Elorza - Frontiers in molecular biosciences, 2021 - frontiersin.org
Copper is essential for life processes like energy metabolism, reactive oxygen species
detoxification, iron uptake, and signaling in eukaryotic organisms. Mitochondria gather copper for …

[HTML][HTML] Role of oxidative stress as key regulator of muscle wasting during cachexia

J Ábrigo, AA Elorza, CA Riedel, C Vilos… - … medicine and cellular …, 2018 - hindawi.com
Skeletal muscle atrophy is a pathological condition mainly characterized by a loss of muscular
mass and the contractile capacity of the skeletal muscle as a consequence of muscular …

Fission and selective fusion govern mitochondrial segregation and elimination by autophagy

G Twig, A Elorza, AJA Molina, H Mohamed… - The EMBO …, 2008 - embopress.org
Accumulation of depolarized mitochondria within β‐cells has been associated with oxidative
damage and development of diabetes. To determine the source and fate of depolarized …

[HTML][HTML] High throughput microplate respiratory measurements using minimal quantities of isolated mitochondria

…, MD Brand, S Petrosyan, D Ashok, AA Elorza… - PloS one, 2011 - journals.plos.org
Recently developed technologies have enabled multi-well measurement of O 2 consumption,
facilitating the rate of mitochondrial research, particularly regarding the mechanism of …

Mitochondrial networking protects β-cells from nutrient-induced apoptosis

…, JD Wikstrom, L Stiles, G Las, H Mohamed, A Elorza… - Diabetes, 2009 - Am Diabetes Assoc
OBJECTIVE Previous studies have reported that β-cell mitochondria exist as discrete organelles
that exhibit heterogeneous bioenergetic capacity. To date, networking activity, and its …

[PDF][PDF] Induction of the mitochondrial NDUFA4L2 protein by HIF-1α decreases oxygen consumption by inhibiting Complex I activity

…, E Balsa, B Acosta-Iborra, E Fuertes-Yebra, A Elorza… - Cell metabolism, 2011 - cell.com
The fine regulation of mitochondrial function has proved to be an essential metabolic adaptation
to fluctuations in oxygen availability. During hypoxia, cells activate an anaerobic switch …

[PDF][PDF] HIF2α acts as an mTORC1 activator through the amino acid carrier SLC7A5

A Elorza, I Soro-Arnáiz, F Meléndez-Rodríguez… - Molecular cell, 2012 - cell.com
The mammalian target of rapamycin (mTOR) pathway, which is essential for cell proliferation,
is repressed in certain cell types in hypoxia. However, hypoxia-inducible factor 2α (HIF2α) …

Autism-like phenotype and risk gene mRNA deadenylation by CPEB4 mis-splicing

…, H Anta, M Santos-Galindo, V Swarup, A Elorza… - Nature, 2018 - nature.com
Common genetic contributions to autism spectrum disorder (ASD) reside in risk gene
variants that individually have minimal effect sizes. As environmental factors that perturb …

[HTML][HTML] β‐arrestin‐and c‐Src‐dependent degradation of G‐protein‐coupled receptor kinase 2

P Penela, A Elorza, S Sarnago, F MayorJr - The EMBO journal, 2001 - embopress.org
G‐protein‐coupled receptor kinase 2 (GRK2) plays a key role in the regulation of G‐protein‐coupled
receptors (GPCRs). GRK2 expression is altered in several pathological conditions, …