User profiles for A. Eustace

Alexander Eustace

Dublin City University
Verified email at dcu.ie
Cited by 1405

Lysyl oxidase: from basic science to future cancer treatment

T Nishioka, A Eustace, C West - Cell structure and function, 2012 - jstage.jst.go.jp
In this mini-review, we discuss the physiological and pathological roles of lysyl oxidase (LOX)
and its family, LOX-like proteins (LOXL), in relation to prognosis of major cancers. The …

[HTML][HTML] Extended-spectrum β-lactamase genes of Escherichia coli in chicken meat and humans, The Netherlands

…, I Willemsen, M Rijnsburger, A Eustace… - Emerging infectious …, 2011 - ncbi.nlm.nih.gov
We determined the prevalence and characteristics of extended-spectrum β-lactamase (ESBL)
genes of Enterobacteriaceae in retail chicken meat and humans in the Netherlands. Raw …

HER2-family signalling mechanisms, clinical implications and targeting in breast cancer

…, DM Collins, S Toomey, J Crown, AJ Eustace… - Breast cancer research …, 2015 - Springer
Approximately 20 % of human breast cancers (BC) overexpress HER2 protein, and HER2-positivity
is associated with a worse prognosis. Although HER2-targeted therapies have …

ATOM: A system for building customized program analysis tools

A Srivastava, A Eustace - Proceedings of the ACM SIGPLAN 1994 …, 1994 - dl.acm.org
ATOM (Analysis Tools with OM) is a single framework for building a wide range of
customized program analysis tools. It provides the common infrastructure present in all code-…

Value profiling

B Calder, P Feller, A Eustace - Proceedings of 30th Annual …, 1997 - ieeexplore.ieee.org
Identifying variables as invariant or constant at compile-time allows the compiler to perform
optimizations including constant folding, code specialization, and partial evaluation. Some …

[HTML][HTML] Enhanced stability of microRNA expression facilitates classification of FFPE tumour samples exhibiting near total mRNA degradation

…, J Taylor, HR Valentine, JJ Irlam, A Eustace… - British journal of …, 2012 - nature.com
Background: As degradation of formalin-fixed paraffin-embedded (FFPE) samples limits the
ability to profile mRNA expression, we explored factors predicting the success of mRNA …

[HTML][HTML] In vitro Development of Chemotherapy and Targeted Therapy Drug-Resistant Cancer Cell Lines: A Practical Guide with Case Studies

M McDermott, AJ Eustace, S Busschots, L Breen… - Frontiers in …, 2014 - frontiersin.org
The development of a drug-resistant cell line can take from 3 to 18 months. However, little is
published on the methodology of this development process. This article will discuss key …

A 26-gene hypoxia signature predicts benefit from hypoxia-modifying therapy in laryngeal cancer but not bladder cancer

A Eustace, N Mani, PN Span, JJ Irlam, J Taylor… - Clinical cancer …, 2013 - AACR
Purpose: Tumor hypoxia is associated with a poor prognosis, hypoxia modification improves
outcome, and hypoxic status predicts benefit from treatment. Yet, there is no universal …

Identification of cells expressing IL-17A and IL-17F in the lungs of patients with COPD

A Eustace, LJC Smyth, L Mitchell, K Williamson… - Chest, 2011 - Elsevier
Background Lymphocytes secrete IL-17A and IL-17F, which enhance innate immune
responses. IL-17 expression has not been studied in COPD small airways. The aim of this study …

Reversing hypoxic cell chemoresistance in vitro using genetic and small molecule approaches targeting hypoxia inducible factor-1

LM Brown, RL Cowen, C Debray, A Eustace… - Molecular …, 2006 - ASPET
The resistance of hypoxic cells to conventional chemotherapy is well documented. Using
both adenovirus-mediated gene delivery and small molecules targeting hypoxia-inducible …