User profiles for A. MAKRIYANNIS

Alexandros Makriyannis

Northeastern University
Verified email at northeastern.edu
Cited by 37398

CB2 cannabinoid receptor agonists: pain relief without psychoactive effects?

…, J Lai, TW Vanderah, A Makriyannis… - Current opinion in …, 2003 - Elsevier
Cannabinoid receptor agonists significantly diminish pain responses in animal models;
however, they exhibit only modest analgesic effects in humans. The relative lack of efficacy in …

Cannabinoid receptor antagonists: pharmacological opportunities, clinical experience, and translational prognosis

DR Janero, A Makriyannis - Expert opinion on emerging drugs, 2009 - Taylor & Francis
The endogenous cannabinoid (CB) (endocannabinoid) signaling system is involved in a
variety of (patho)physiological processes, primarily by virtue of natural, arachidonic acid-…

Evidence that anandamide‐signaling regulates human sperm functions required for fertilization

…, A Giuffrida, RP Picone, A Makriyannis - Molecular …, 2002 - Wiley Online Library
Ejaculated mammalian sperm require several hours exposure to secretions in female
reproductive tracts, or incubation in appropriate culture medium in vitro, before acquiring the …

Identification and Functional Characterization of Brainstem Cannabinoid CB2 Receptors

…, P Urbani, K Mackie, N Stella, A Makriyannis… - Science, 2005 - science.org
The presence and function of CB 2 receptors in central nervous system (CNS) neurons are
controversial. We report the expression of CB 2 receptor messenger RNA and protein …

Functional role of high-affinity anandamide transport, as revealed by selective inhibition

…, N Stella, A Calignano, SY Lin, A Makriyannis… - Science, 1997 - science.org
Anandamide, an endogenous ligand for central cannabinoid receptors, is released from
neurons on depolarization and rapidly inactivated. Anandamide inactivation is not completely …

Activation of CB2 cannabinoid receptors by AM1241 inhibits experimental neuropathic pain: Pain inhibition by receptors not present in the CNS

…, J Lai, F Porreca, A Makriyannis… - Proceedings of the …, 2003 - National Acad Sciences
We designed AM1241, a selective CB 2 cannabinoid receptor agonist, and used it to test
the hypothesis that CB 2 receptor activation would reverse the sensory hypersensitivity …

CB2 cannabinoid receptor activation produces antinociception by stimulating peripheral release of endogenous opioids

…, G Davar, A Makriyannis… - Proceedings of the …, 2005 - National Acad Sciences
CB 2 cannabinoid receptor-selective agonists are promising candidates for the treatment of
pain. CB 2 receptor activation inhibits acute, inflammatory, and neuropathic pain responses …

[HTML][HTML] Crystal structure of the human cannabinoid receptor CB1

…, B Wu, Q Zhao, MA Hanson, LM Bohn, A Makriyannis… - Cell, 2016 - cell.com
Cannabinoid receptor 1 (CB 1 ) is the principal target of Δ 9 -tetrahydrocannabinol (THC), a
psychoactive chemical from Cannabis sativa with a wide range of therapeutic applications …

Crystal structures of agonist-bound human cannabinoid receptor CB1

…, H Liu, MA Hanson, S Zhao, LM Bohn, A Makriyannis… - Nature, 2017 - nature.com
The cannabinoid receptor 1 (CB 1 ) is the principal target of the psychoactive constituent of
marijuana, the partial agonist Δ 9 -tetrahydrocannabinol (Δ 9 -THC) 1 . Here we report two …

Endocannabinoids acting at vascular CB1 receptors mediate the vasodilated state in advanced liver cirrhosis

…, L Wang, F Mirshahi, AD Khanolkar, A Makriyannis… - Nature medicine, 2001 - nature.com
Advanced cirrhosis is associated with generalized vasodilation of unknown origin, which
contributes to mortality. Cirrhotic patients are endotoxemic, and activation of vascular …