α 2 adrenergic receptors mediate many of the physiological actions of the endogenous
catecholamines adrenaline and noradrenaline, and are targets of several therapeutic agents, α 2 …

Heparin-like polysaccharides possess the capacity to inhibit cancer cell proliferation,
angiogenesis, heparanase-mediated cancer cell invasion, and cancer cell adhesion to vascular …

The α 2 -adrenergic receptors (α 2 -ARs) belong to the large family of rhodopsinlike G-protein–coupled
receptors that share a common structure of seven transmembrane (TM) α-helices. …

Chinese hamster ovary (CHO) cells stably transfected to express different densities of the
human α 2A -, α 2B - and α 2C -adrenoceptor subtypes, were used to characterize the …

The interaction between α2β1 integrin (GPIa/IIa, VLA-2) and vascular collagen is one of the
initiating events in thrombus formation. Here, we describe two structurally similar …

We present a mechanism for agonist-promoted α 2A -adrenergic receptor (α 2A -AR)
activation based on structural, pharmacological, and theoretical evidence of the interactions …

1 Zebrafish has five distinct α 2 ‐adrenoceptors. Two of these, α 2Da and α 2Db , represent a
duplicated, fourth α 2 ‐adrenoceptor subtype, while the others are orthologue of the human …

TGF-β regulates several steps in cancer metastasis, including the establishment of bone
metastatic lesions. TGF-β is released from bone during osteoclastic bone resorption and it …

Phenoxybenzamine (PB), a classical α-adrenergic antagonist, binds irreversibly to the α-adrenergic
receptors (ARs). Amino acid sequence alignments and the predicted helical …

The structural determinants of catechol hydroxyl interactions with adrenergic receptors were
examined using 12 α 2 ‐adrenergic agonists and a panel of mutated human α 2A ‐…