User profiles for A. Parrill
Abby ParrillUniversity of Memphis Verified email at memphis.edu Cited by 5884 |
Molecular mechanisms of lysophosphatidic acid action
G Tigyi, AL Parrill - Progress in lipid research, 2003 - Elsevier
Lysophosphatidic acid (radyl-glycerol-phosphate, LPA) has captured the interest of lipid
biochemists, cell biologists, physiologists, and physicians alike due to its myriad biological …
biochemists, cell biologists, physiologists, and physicians alike due to its myriad biological …
[HTML][HTML] G protein-coupled receptors: the evolution of structural insight
SB Gacasan, DL Baker, AL Parrill - AIMS biophysics, 2017 - ncbi.nlm.nih.gov
G protein-coupled receptors (GPCR) comprise a diverse superfamily of over 800 proteins
that have gained relevance as biological targets for pharmaceutical drug design. Although …
that have gained relevance as biological targets for pharmaceutical drug design. Although …
[PDF][PDF] S1P1-selective in vivo-active agonists from high-throughput screening: off-the-shelf chemical probes of receptor interactions, signaling, and fate
The essential role of the sphingosine 1-phosphate (S1P) receptor S1P 1 in regulating
lymphocyte trafficking was demonstrated with the S1P 1 -selective nanomolar agonist, SEW2871. …
lymphocyte trafficking was demonstrated with the S1P 1 -selective nanomolar agonist, SEW2871. …
Dual activity lysophosphatidic acid receptor pan-antagonist/autotaxin inhibitor reduces breast cancer cell migration in vitro and causes tumor regression in vivo
…, Y Fujiwara, J Liu, JI Fells, D Perygin, AL Parrill… - Cancer research, 2009 - AACR
Signal transduction modifiers that modulate the lysophosphatidic acid (LPA) pathway have
potential as anticancer agents. Herein, we describe metabolically stabilized LPA analogues …
potential as anticancer agents. Herein, we describe metabolically stabilized LPA analogues …
[HTML][HTML] GPRC6A mediates the non-genomic effects of steroids
The identity of the putative G-protein coupled receptor (GPCR) that mediates the non-genomic
effects of androgens is unknown. We present in vitro and in vivo evidence that the orphan …
effects of androgens is unknown. We present in vitro and in vivo evidence that the orphan …
[HTML][HTML] Unique ligand selectivity of the GPR92/LPA5 lysophosphatidate receptor indicates role in human platelet activation
Lysophosphatidic acid (LPA) is a ligand for LPA 1–3 of the endothelial differentiation gene
family G-protein-coupled receptors, and LPA 4–8 is related to the purinergic family G-protein-…
family G-protein-coupled receptors, and LPA 4–8 is related to the purinergic family G-protein-…
[PDF][PDF] Phospholipase D2-dependent inhibition of the nuclear hormone receptor PPARγ by cyclic phosphatidic acid
Cyclic phosphatidic acid (1-acyl-2,3-cyclic-glycerophosphate, CPA), one of nature's simplest
phospholipids, is found in cells from slime mold to humans and has a largely unknown …
phospholipids, is found in cells from slime mold to humans and has a largely unknown …
Gold nanorods carrying paclitaxel for photothermal-chemotherapy of cancer
…, J Johnson, L Xu, DL Baker, AL Parrill… - Bioconjugate …, 2013 - ACS Publications
Nanotechnology-based photothermal therapy has emerged as a promising treatment for
cancer during the past decade. However, heterogeneous laser heating and limited light …
cancer during the past decade. However, heterogeneous laser heating and limited light …
[HTML][HTML] Identification of Edg1 receptor residues that recognize sphingosine 1-phosphate
AL Parrill, D Wang, DL Bautista… - Journal of Biological …, 2000 - ASBMB
Originating from its DNA sequence, a computational model of the Edg1 receptor has been
developed that predicts critical interactions with its ligand, sphingosine 1-phosphate. The …
developed that predicts critical interactions with its ligand, sphingosine 1-phosphate. The …
Molecular basis for lysophosphatidic acid receptor antagonist selectivity
Recent characterization of lysophosphatidic acid (LPA) receptors has made possible
studies elucidating the structure–activity relationships (SAR) for agonist activity at individual …
studies elucidating the structure–activity relationships (SAR) for agonist activity at individual …