Within the last 15 years, multiple new signal transduction pathways within cells have been
discovered. Many of these pathways belong to what is now termed ‘the mitogen-activated …

… Adly Yacoub; Adly Yacoub … Paul Dent, Adly Yacoub, Joseph Contessa, Ruben Caron,
George Amorino, Kristoffer Valerie, Michael P. Hagan, Steven Grant, Rupert Schmidt-Ullrich; …

Exposure of tumor cells to clinically relevant doses of ionizing radiation causes DNA damage
as well as mitochondria-dependent generation of reactive oxygen species. DNA damage …

Background Based on the encouraging activity and manageable safety profile observed in
a phase 1 study, the ECHELON-2 trial was initiated to compare the efficacy and safety of …

PURPOSE Observation is the current standard of care for smoldering multiple myeloma. We
hypothesized that early intervention with lenalidomide could delay progression to …

Signal transducer and activator of transcription 3 (Stat3) is a key mediator in the development
of many cancers. For 20 years, it has been assumed that Stat3 mediates its biological …

Abstract Characterization of the genetic landscape of Alzheimer’s disease (AD) and related
dementias (ADD) provides a unique opportunity for a better understanding of the associated …

Staphylococcus aureus arthritis is usually caused by bacteremia and is highly destructive.
Controlled studies on septic arthritis in humans are difficult to perform, because the time of …

Prior studies have reported high response rates with recombinant interferon-α (rIFN-α) therapy
in patients with essential thrombocythemia (ET) and polycythemia vera (PV). To further …

Pemetrexed (ALIMTA, Lilly) is a folate antimetabolite that has been approved by the US
Food and Drug Administration for the treatment of non–small cell lung cancer and has been …