MAPK pathways in radiation responses
P Dent, A Yacoub, PB Fisher, MP Hagan, S Grant - Oncogene, 2003 - nature.com
Within the last 15 years, multiple new signal transduction pathways within cells have been
discovered. Many of these pathways belong to what is now termed ‘the mitogen-activated …
discovered. Many of these pathways belong to what is now termed ‘the mitogen-activated …
Stress and radiation-induced activation of multiple intracellular signaling pathways
P Dent, A Yacoub, J Contessa, R Caron… - Radiation …, 2003 - meridian.allenpress.com
… Adly Yacoub; Adly Yacoub … Paul Dent, Adly Yacoub, Joseph Contessa, Ruben Caron,
George Amorino, Kristoffer Valerie, Michael P. Hagan, Steven Grant, Rupert Schmidt-Ullrich; …
George Amorino, Kristoffer Valerie, Michael P. Hagan, Steven Grant, Rupert Schmidt-Ullrich; …
Radiation-induced cell signaling: inside-out and outside-in
Exposure of tumor cells to clinically relevant doses of ionizing radiation causes DNA damage
as well as mitochondria-dependent generation of reactive oxygen species. DNA damage …
as well as mitochondria-dependent generation of reactive oxygen species. DNA damage …
Brentuximab vedotin with chemotherapy for CD30-positive peripheral T-cell lymphoma (ECHELON-2): a global, double-blind, randomised, phase 3 trial
…, E Weidmann, M Wilhelm, M Witzens-Harig, A Yacoub… - The Lancet, 2019 - thelancet.com
Background Based on the encouraging activity and manageable safety profile observed in
a phase 1 study, the ECHELON-2 trial was initiated to compare the efficacy and safety of …
a phase 1 study, the ECHELON-2 trial was initiated to compare the efficacy and safety of …
[HTML][HTML] Randomized trial of lenalidomide versus observation in smoldering multiple myeloma
…, RZ Orlowski, JL Kaufman, AM Yacoub… - Journal of Clinical …, 2020 - ncbi.nlm.nih.gov
PURPOSE Observation is the current standard of care for smoldering multiple myeloma. We
hypothesized that early intervention with lenalidomide could delay progression to …
hypothesized that early intervention with lenalidomide could delay progression to …
[HTML][HTML] Mitochondrial localized Stat3 promotes breast cancer growth via phosphorylation of serine 727
Q Zhang, V Raje, VA Yakovlev, A Yacoub… - Journal of Biological …, 2013 - ASBMB
Signal transducer and activator of transcription 3 (Stat3) is a key mediator in the development
of many cancers. For 20 years, it has been assumed that Stat3 mediates its biological …
of many cancers. For 20 years, it has been assumed that Stat3 mediates its biological …
[HTML][HTML] New insights into the genetic etiology of Alzheimer's disease and related dementias
Abstract Characterization of the genetic landscape of Alzheimer’s disease (AD) and related
dementias (ADD) provides a unique opportunity for a better understanding of the associated …
dementias (ADD) provides a unique opportunity for a better understanding of the associated …
Experimental Staphylococcus aureus arthritis in mice
T Bremell, S Lange, A Yacoub, C Ryden… - Infection and …, 1991 - Am Soc Microbiol
Staphylococcus aureus arthritis is usually caused by bacteremia and is highly destructive.
Controlled studies on septic arthritis in humans are difficult to perform, because the time of …
Controlled studies on septic arthritis in humans are difficult to perform, because the time of …
Pegylated interferon alfa-2a for polycythemia vera or essential thrombocythemia resistant or intolerant to hydroxyurea
A Yacoub, J Mascarenhas, H Kosiorek… - Blood, The Journal …, 2019 - ashpublications.org
Prior studies have reported high response rates with recombinant interferon-α (rIFN-α) therapy
in patients with essential thrombocythemia (ET) and polycythemia vera (PV). To further …
in patients with essential thrombocythemia (ET) and polycythemia vera (PV). To further …
Sorafenib enhances pemetrexed cytotoxicity through an autophagy-dependent mechanism in cancer cells
MD Bareford, MA Park, A Yacoub, HA Hamed, Y Tang… - Cancer research, 2011 - AACR
Pemetrexed (ALIMTA, Lilly) is a folate antimetabolite that has been approved by the US
Food and Drug Administration for the treatment of non–small cell lung cancer and has been …
Food and Drug Administration for the treatment of non–small cell lung cancer and has been …