Non-invasive imaging of reporter gene expression using different imaging modalities is
increasing its role for the in vivo assessment of molecular processes. Multimodality imaging …

Cancer gender disparities have been observed for a variety of human malignancies.
Thyroid cancer is one such example where there is a dramatic difference in the incidence, …

During the past decade remarkable progress in molecular genetics and the possibility of
manipulating cells so that the expression of genes can directly ‘report' on drug activity has …

There is a growing interest in peroxisome proliferator-activated receptors (PPARs) as major
players in the regulation of lipid and carbohydrate metabolism. Drugs targeting PPARs were …

By the use of in vivo imaging, we investigated the dynamics of estrogen receptor (ER)
activity in intact, ovariectomized, and hormone-replaced estrogen response element-luciferase …

Cancer is the result of a series of genetic and epigenetic mutations that evolve over years
even decades and lead to the transformed phenotype. Paradoxically, most methods …

Using a mouse model engineered to measure estrogen receptor (ER) transcriptional activity
in living organisms, we investigated the effect of long-term (21 d) hormone replacement on …

We report here the finding of a new pharmacological activity of a well known antagonist of
peroxisome proliferator-activated receptors (PPARs). PPARs belong to the family of nuclear …

Wolbachia pipientis is an intracellular bacterial endosymbiont of arthropods and filarial
nematodes. Six main supergroups of W. pipientis have been described: supergroups A, B, E, and …

The development of novel drugs is a lengthy process requiring years of preclinical research
and many steps indispensable to ensure that the molecule of interest can be administered to …