2,3,7,8-Tetrachlorodibenzo-p-Dioxin and Related Halogenated Aromatic Hydrocarbons: Examination of the Mechanism of Toxicity

A Poland, JC Knutson - Annual review of pharmacology and …, 1982 - annualreviews.org
The chlorinated dibenzo-p-dioxins, dibenzofurans, azo (xy) benzenes, naphн thalenes, and
biphenyls and the brominated biphenyls, collectively termed the halogenated aromatic …

[HTML][HTML] Stereospecific, high affinity binding of 2, 3, 7, 8-tetrachlorodibenzo-p-dioxin by hepatic cytosol. Evidence that the binding species is receptor for induction of …

A Poland, E Glover, AS Kende - Journal of Biological Chemistry, 1976 - Elsevier
We previously hypothesized that the genetic trait of aromatic hydrocarbon nonresponsiveness
(the failure in certain inbred strains of mice of polycyclic hydrocarbons to induce aryl …

Cloning of the Ah-receptor cDNA reveals a distinctive ligand-activated transcription factor.

KM Burbach, A Poland… - Proceedings of the …, 1992 - National Acad Sciences
A cDNA encoding the murine Ah receptor (Ahb-1 allele for aromatic hydrocarbon
responsiveness) has been isolated and characterized. Analysis of the deduced protein sequence …

Genetic expression of aryl hydrocarbon hydroxylase activity: induction of monooxygenase activities and cytochrome P1-450 formation by 2, 3, 7, 8-tetrachlorodibenzo …

AP Poland, E Glover, JR Robinson… - Journal of Biological …, 1974 - Elsevier
The intraperitoneal administration of aromatic hydrocarbons such as 3-methylcholanthrene,
b-naphthoflavone, or naphthacene induces several monooxygenase activities and the new …

[PDF][PDF] Analysis of the four alleles of the murine aryl hydrocarbon receptor.

A Poland, D Palen, ED Glover - Molecular pharmacology, 1994 - Citeseer
The cDNAs for the four munne aryl hydrocarbon(Ah) receptor alleles were cloned and sequenced,
and the deduced amino acid sequences were compared. The Ah’> 1 allele encodes a …

[PDF][PDF] The aryl hydrocarbon receptor and aryl hydrocarbon receptor nuclear translocator protein show distinct subcellular localizations in Hepa 1c1c7 cells by …

RS Pollenz, CA Sattler, A Poland - Molecular pharmacology, 1994 - Citeseer
The aryl hydrocarbon receptor (AhR) and AhR nuclear translocator (Amt) protein were
evaluated in the Hepa 1ci c7 (Hepa-1) cell line by indirect immunofluorescence microscopy and …

Tumour promotion by TCDD in skin of HRS/J hairless mice

A Poland, D Palen, E Glover - Nature, 1982 - nature.com
2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) serves as the prototype for a group of environmental
toxicants, the halogenated aromatic hydrocarbons 1–3 , which evoke a characteristic …

2, 3, 7, 8-Tetrachlorodibenzo-p-dioxin: segregation of toxicity with the Ah locus

A POLAND, E GLOVER - Molecular pharmacology, 1980 - ASPET
2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) and related halogenated aromatic hydrocarbons
(a) produce a similar pattern of toxic responses; (b) induce a battery of enzymes, including …

[HTML][HTML] Binding of aryl hydrocarbon receptor (AhR) to AhR-interacting protein: the role of hsp90

DR Bell, A Poland - Journal of Biological Chemistry, 2000 - ASBMB
The aryl hydrocarbon receptor (AhR) has been shown to interact with an immunophilin-like
molecule known as AhR-interacting protein (AIP) and to enhance AhR function. We show …

Strong evidence from studies with brachymorphic mice and pentachlorophenol that 1′-sulfoöxysafrole is the major ultimate electrophilic and carcinogenic metabolite …

EW Boberg, EC Miller, JA Miller, A Poland, A Liem - Cancer research, 1983 - AACR
The role of sulfation of 1′-hydroxysafrole in the formation of hepatic macromolecular adducts
and in hepatic tumor formation in mice given 1′-hydroxysafrole was investigated by the …