Lethal Effect of Phenothiazine Neuroleptics on the Pathogenic Protozoan Leishmania donovani
RD Pearson, AA Manian, JL Harcus, D Hall, EL Hewlett - Science, 1982 - science.org
Phenothiazine drugs, which are widely used for their antipsychotic, antianxiety, and
antiemetic effects, have been found to have protozoacidal effects on the human pathogen …
antiemetic effects, have been found to have protozoacidal effects on the human pathogen …
A comparative study of certain pharmacologic responses following acute and chronic administrations of chlordiazepoxide
ME Goldberg, AA Manian, DH Efron - Life Sciences, 1967 - Elsevier
Certain pharmacological responses in mice and rats were contrasted following acute and
chronic administrations of chlordiazepoxide. In both species, studies were conducted after oral …
chronic administrations of chlordiazepoxide. In both species, studies were conducted after oral …
Effects of several tricyclic antidepressants on the hemodynamics and myocardial contractility of the anesthetized dogs
…, ML Steenberg, JM Perel, AA Manian… - European Journal of …, 1977 - Elsevier
Cardiovascular effects of several imipramine analogs were investigated in the anesthetized
mongrel dogs. Significant reduction in the cardiac output produced by lower doses (2.5 mg/…
mongrel dogs. Significant reduction in the cardiac output produced by lower doses (2.5 mg/…
Effects of chlorpromazine and three metabolites on behavioral responses in rats
H Barry III, ML Steenberg, AA Manian, JP Buckley - Psychopharmacologia, 1974 - Springer
Abstract Effects of chlorpromazine (CPZ) and three metabolites (3,7-dihydroxy-CPZ; 7,8-dihydroxy-CPZ;
7-hydroxy-CPZ) on behavioral performance of rats were tested by three methods…
7-hydroxy-CPZ) on behavioral performance of rats were tested by three methods…
Reactivity of various phenothiazine derivatives with oxygen and oxygen radicals
RE Heikkila, G Cohen, AA Manian - Biochemical Pharmacology, 1975 - Elsevier
7,8-Dihydroxychlorpromazine, 7,8-dihydroxyprochlorperazine and 7,8-dihydroxyperphenazine
all reacted with O 2 to make hydrogen peroxide (H 2 O 2 ). The rate of reaction between …
all reacted with O 2 to make hydrogen peroxide (H 2 O 2 ). The rate of reaction between …
[PDF][PDF] Hydroxylated chlorpromazine metabolites: positive inotropic action and the release of catecholamines
…, TAI AKERA, TM BRODY, AA MANIAN - Molecular …, 1977 - Citeseer
TEMMA, KYOSUKE, AKERA, TAI, BRODY, THEODORE M. & MANIAN, ALBERT A.(1977)
Hydroxylated chlorpromazine metabolites: positive inotropic action and the release of …
Hydroxylated chlorpromazine metabolites: positive inotropic action and the release of …
3H-Haloperidol binding to dopamine receptors in rat corpus striatum: influence of chlorpromazine metabolites and derivatives
I Creese, AA Manian, TD Prosser, SH Snyder - European Journal of …, 1978 - Elsevier
A series of chlorpromazine metabolites and derivatives have been assayed for their ability
to compete with 3 H-haloperidol binding to dopamine receptors in membranes of rat corpus …
to compete with 3 H-haloperidol binding to dopamine receptors in membranes of rat corpus …
Actions of phenothiazine analogues on dopamine-sensitive adenylate cyclase in neuronal and glial-enriched fractions from rat brain
GC Palmer, AA Manian - Biochemical Pharmacology, 1976 - Elsevier
Dopamine (DA) at 10 −4 M readily activated adenylate cyclase in homogenates of neuronal
and glial-enriched fractions prepared from rat cerebral cortex, thalamus, striatum and the …
and glial-enriched fractions prepared from rat cerebral cortex, thalamus, striatum and the …
Radioassay of chlorpromazine and its metabolites in plasma
DH Efron, SR Harris, AA Manian, LE Gaudette - Psychopharmacologia, 1971 - Springer
Conditions have been established for the quantitative formation of radiolabeled derivatives
of chlorpromazine, chlorpromazine sulfoxide and their demethylated analogs in plasma …
of chlorpromazine, chlorpromazine sulfoxide and their demethylated analogs in plasma …
Pharmacology of mono‐and disubstituted chlorpromazine metabolites
…, ML Steenberg, HB Iii, AA Manian - Journal of …, 1973 - Wiley Online Library
Chlorpromazine and 10 of its mono‐ and disubstituted metabolites were investigated for their
effects on the CNS of male rats and mice. All of the compounds decreased motor activity …
effects on the CNS of male rats and mice. All of the compounds decreased motor activity …