Elucidation of the rate-limiting step in norepinephrine biosynthesis in the perfused guinea-pig heart

M Levitt, S Spector, A Sjoerdsma… - Journal of Pharmacology …, 1965 - ASPET
Guinea-pig hearts were perfused with varying concentrations of the norepinephrine
precursors, tyrosine, 3,4-dihydroxyphenylalanine (dopa) and 3,4-dihydroxyphenethylamine (…

Tryptophan hydroxylation: measurement in pineal gland, brainstem, and carcinoid tumor

W Lovenberg, E Jequier, A Sjoerdsma - Science, 1967 - science.org
Development of a rapid and sensitive radioassay has permitted study of the conversion of
tryptophan to 5-hydroxytryptophan in mammalian tissues. Of normal tissues examined, beef …

Tryptophan hydroxylase inhibition: the mechanism by which p-chlorophenylalanine depletes rat brain serotonin

E JÉQUIER, W LOVENBERG, A SJOERDSMA - Molecular pharmacology, 1967 - ASPET
Administration of the specific serotonin depletor p-chlorophenylalanine to rats results in
marked inhibition of tryptophan hydroxylase of the brain. The enzyme inhibition can be …

Serotonin, norepinephrine, and related compounds in bananas

TP Waalkes, A Sjoerdsma, CR Creveling, H Weissbach… - Science, 1958 - science.org
8. B. Commoner et al., ibid. 126, 57 (1957). 9. Since this paper was submitted, the
proceedings of the Gatlinburg symposium on photosynthesis have appeared [H. Gaffron, Ed., …

Neurologic effects of tryptophan in patients receiving a monoamine oxidase inhibitor

JA Oates, A Sjoerdsma - Neurology, 1960 - AAN Enterprises
MATERIALS AND METHODS The subjects were 7 hospitalized patients, 4 females and 3
males, ranging in age from 18 to. 53. All had essential hypertension which in 1 case had been …

Reversal of Chloroquine Resistance in Malaria Parasite Plasmodium falciparum by Desipramine

AJ Bitonti, A Sjoerdsma, PP McCann, DE Kyle… - Science, 1988 - science.org
Desipramine and several other tricyclic antidepressant drugs reverse chloroquine resistance
in Plasmodium falciparum in vitro at concentrations observed in the plasma of human …

Physiologically active amines in common fruits and vegetables

S Udenfriend, W Lovenberg, A Sjoerdsma - Archives of Biochemistry and …, 1959 - Elsevier
5-Hydroxytryptamine, tryptamine, tyramine, 3,4-dihydroxyphenylethylamine and norepinephrine
have been identified and assayed in a large number of fruits and vegetables. The …

Inhibition of serotonin synthesis by para-chlorophenylalanine in patients with the carcinoid syndrome

…, W Lovenberg, A Sjoerdsma - New England Journal of …, 1967 - Mass Medical Soc
ALTHOUGH the role of 5-hydroxytryptamine (serotonin, 5HT) in the pathophysiology of the
carcinoid syndrome, and especially in flush production, has been seriously questioned, 2 the …

Formation of indole-3-acetic acid and trytamine in animals. A method for estimation of indole-3-acetic acid in tissues.

H Weissbach, W King, A Sjoerdsma… - Journal of Biological …, 1959 - cabdirect.org
Urine, 4 ml., and 0.36 ml. 12 N HCl were heated at 100 C. for 15 min. The mixture was shaken
with 10 ml. chloroform and, after centrifuging, 9 ml. chloroform was extracted with 0.6 ml. …

Monoamine oxidase inhibitors, tyramine, and cheese

D Horwitz, W Lovenberg, K Engelman, A Sjoerdsma - Jama, 1964 - jamanetwork.com
Marked potentiation of the pressor effects of tyramine hydrochloride, given orally and
intravenously, was demonstrated in patients receiving a monoamine oxidase (MAO) inhibitor. …