Therapeutic targeting of mitochondrial one-carbon metabolism in cancer
AS Dekhne, Z Hou, A Gangjee, LH Matherly - Molecular cancer therapeutics, 2020 - AACR
One-carbon (1C) metabolism encompasses folate-mediated 1C transfer reactions and related
processes, including nucleotide and amino acid biosynthesis, antioxidant regeneration, …
processes, including nucleotide and amino acid biosynthesis, antioxidant regeneration, …
Novel Pyrrolo[3,2-d]pyrimidine Compounds Target Mitochondrial and Cytosolic One-carbon Metabolism with Broad-spectrum Antitumor Efficacy
Folate-dependent one-carbon (C1) metabolism is compartmentalized into the mitochondria
and cytosol and supports cell growth through nucleotide and amino acid biosynthesis. …
and cytosol and supports cell growth through nucleotide and amino acid biosynthesis. …
Cellular pharmacodynamics of a novel pyrrolo [3, 2-d] pyrimidine inhibitor targeting mitochondrial and cytosolic one-carbon metabolism
Folate-dependent one-carbon (C1) metabolism is compartmentalized in the mitochondria
and cytosol and is a source of critical metabolites for proliferating tumors. Mitochondrial C1 …
and cytosol and is a source of critical metabolites for proliferating tumors. Mitochondrial C1 …
Design, synthesis and biological evaluation of novel pyrrolo [2, 3-d] pyrimidine as tumor-targeting agents with selectivity for tumor uptake by high affinity folate …
Tumor-targeted 6-substituted pyrrolo[2,3-d]pyrimidine benzoyl compounds based on 2 were
isosterically modified at the 4-carbon bridge by replacing the vicinal (C11) carbon by …
isosterically modified at the 4-carbon bridge by replacing the vicinal (C11) carbon by …
Mitochondrial and cytosolic one-carbon metabolism is a targetable metabolic vulnerability in cisplatin-resistant ovarian cancer
A Wallace-Povirk, C O'Connor, AS Dekhne, X Bao… - Molecular Cancer …, 2024 - AACR
One-carbon (C1) metabolism is compartmentalized between the cytosol and mitochondria
with the mitochondrial C1 pathway as the major source of glycine and C1 units for cellular …
with the mitochondrial C1 pathway as the major source of glycine and C1 units for cellular …
Dual targeting mitochondrial and cytosolic one-carbon metabolism via the proton-coupled folate transporter with novel 5-substituted pyrrolo[3,2-d]pyrimidine …
Cellular one-carbon (1C) metabolism generates a host of metabolites especially critical to
cancer cells. Classical 1C inhibitors often primarily target a single enzyme, commonly leading …
cancer cells. Classical 1C inhibitors often primarily target a single enzyme, commonly leading …
[PDF][PDF] External beam radiation therapy carries lower risk of sexual dysfunction as compared to radical prostatectomy in treatment of patients with localized prostate …
AS Dekhne - Clinical Research in Practice: The Journal …, 2021 - digitalcommons.wayne.edu
… Freeman’s prostate cancer was classified as T1c and favorable … Freeman’s wife had recently
passed after a lengthy battle … Freeman’s primary concern was preservation of his sexual and …
passed after a lengthy battle … Freeman’s primary concern was preservation of his sexual and …
Correction: Novel Pyrrolo[3,2-d]Pyrimidine Compounds Target Mitochondrial and Cytosolic One-Carbon Metabolism with Broad-spectrum Antitumor Efficacy
Following publication of the original version of this article (1), a resynthesis and reevaluation
of a fresh lot of our lead compound AGF347 afforded improved in vitro biological activity …
of a fresh lot of our lead compound AGF347 afforded improved in vitro biological activity …
[BOOK][B] Therapeutic Dual-targeting of Cytosolic and Mitochondrial One-carbon Metabolism
AS Dekhne - 2019 - search.proquest.com
… From commiserating about grad school classes and fellowship grants, to always reminding
me to remain thankful I did not have Tet-On in my project, Adrianne’s advice has always been …
me to remain thankful I did not have Tet-On in my project, Adrianne’s advice has always been …
[PDF][PDF] A bioinformatics approach to increasing the solubility of protein-based drugs
A Dekhne - 2014 - deepblue.lib.umich.edu
… on heavy experimental testing of the protein’s stability, which is highly time consuming and
… the protein’s stability before it is created. While a protein-based drug’s efficacy is determined …
… the protein’s stability before it is created. While a protein-based drug’s efficacy is determined …