User profiles for Adolfo Borges

Adolfo Borges

Centro para el Desarrollo de la Investigación Científica
Verified email at cedic.org.py
Cited by 3349

Snake Venomics of the Central American Rattlesnake Crotalus simus and the South American Crotalus durissus Complex Points to Neurotoxicity as an Adaptive Paedomorphic …

…, M Flores-Diaz, MC Dos Santos, A Borges… - Journal of proteome …, 2010 - ACS Publications
We report a comparative venomic and antivenomic characterization of the venoms of
newborn and adult specimens of the Central American rattlesnake, Crotalus simus, and of the …

A common structural motif in thiamin pyrophosphate-binding enzymes

CF Hawkins, A Borges, RN Perham - FEBS letters, 1989 - Elsevier
The amino acid sequences of a wide range of enzymes that utilize thiamin pyrophosphate (TPP)
as cofactor have been compared. A common sequence motif approximately 30 residues …

Snake population venomics and antivenomics of Bothrops atrox: Paedomorphism along its transamazonian dispersal and implications of geographic venom variability …

JJ Calvete, L Sanz, A Pérez, A Borges, AM Vargas… - Journal of …, 2011 - Elsevier
We describe two geographically differentiated venom phenotypes across the wide distribution
range of Bothrops atrox, from the Colombian Magdalena Medio Valley through Puerto …

Snake venomics and antivenomics of Bothrops colombiensis, a medically important pitviper of the Bothrops atrox-asper complex endemic to Venezuela: Contributing …

JJ Calvete, A Borges, Á Segura, M Flores-Díaz… - Journal of …, 2009 - Elsevier
The taxonomic status of the medically important pitviper of the Bothrops atrox-asper complex
endemic to Venezuela, which has been classified as Bothrops colombiensis, remains …

Subtype specificity of scorpion β-toxin Tz1 interaction with voltage-gated sodium channels is determined by the pore loop of domain 3

E Leipold, A Hansel, A Borges, SH Heinemann - Molecular pharmacology, 2006 - ASPET
Voltage-gated sodium (Na v ) channels are modulated by a variety of specific neurotoxins.
Scorpion β-toxins affect the voltage-dependence of channel gating: In their presence, Na v …

Impact of Regional Variation in Bothrops asper Snake Venom on the Design of Antivenoms: Integrating Antivenomics and Neutralization Approaches

…, M Villalta, G León, R Estrada, A Borges… - Journal of Proteome …, 2010 - ACS Publications
Intraspecific snake venom variations have implications in the preparation of venom pools for
the generation of antivenoms. The impact of such variation in the cross-reactivity of …

µO-Conotoxins Inhibit NaV Channels by Interfering with their Voltage Sensors in Domain-2

E Leipold, H DeBie, S Zorn, B Adolfo, BM Olivera… - Channels, 2007 - Taylor & Francis
The µO-conotoxins MrVIA and MrVIB are 31-residue peptides from Conus marmoreus,
belonging to the O-superfamily of conotoxins with three disulfide bridges. They have attracted …

Venom diversity in the Neotropical scorpion genus Tityus: Implications for antivenom design emerging from molecular and immunochemical analyses across endemic …

A Borges, B Lomonte, Y Angulo, HA de Patiño… - Acta Tropica, 2020 - Elsevier
Scorpions of the Neotropical genus Tityus are responsible for most severe envenomations
in the Caribbean, South America, and Lower Central America (LCA). Although Tityus is …

Molecular systematics of the neotropical scorpion genus Tityus (Buthidae): the historical biogeography and venom antigenic diversity of toxic Venezuelan species

A Borges, E Bermingham, N Herrera, MJ Alfonzo… - Toxicon, 2010 - Elsevier
We provide a mitochondrial DNA-based phylogenetic hypothesis for 21 Tityus species
collected in Venezuela, Trinidad, Brazil and Panama, including 12 taxa known to be toxic to …

An overview of Tityus cisandinus scorpion venom: Transcriptome and mass fingerprinting reveal conserved toxin homologs across the Amazon region and novel …

…, E Kalapothakis, C Chávez-Olórtegui, A Borges - International Journal of …, 2023 - Elsevier
Tityus cisandinus, a neglected medically important scorpion in Ecuadorian and Peruvian
Amazonia, belongs to a complex of species related to the eastern Amazon endemic Tityus …