Cells undergo a variety of biological responses when placed in hypoxic conditions, including
activation of signalling pathways that regulate proliferation, angiogenesis and death. …

Comprehensive gene expression patterns generated from cDNA microarrays were correlated
with detailed clinico-pathological characteristics and clinical outcome in an unselected …

In 135 primary breast cancers, there was a significant inverse relation between epidermal-growth-factor
receptor (EGFR) and oestrogen receptor (ER) status, and a significant …

Circulating nucleic acids have been shown to have potential as non‐invasive diagnostic
markers in cancer. We therefore investigated whether microRNAs also have diagnostic utility by …

The cellular response to hypoxia includes the hypoxia-inducible factor-1 (HIF-1)-induced
transcription of genes involved in diverse processes such as glycolysis and angiogenesis. …

The transcriptional complex hypoxia-inducible factor-1 (HIF-1) has emerged as an important
mediator of gene expression patterns in tumors,although the range of responding genes is …

Angiogenesis is a key process in tumor growth and metastasis and is a major independent
prognostic factor in breast cancer. A range of cytokines stimulate the tumor neovasculature, …

Cellular microvesicles and nanovesicles (exosomes) are involved in many disease
processes and have major potential as biomarkers. However, developments in this area are …

Purpose To assess the clinical significance of tumor-infiltrating FOXP3-positive regulatory T
cells (T R ) in breast cancer patients with long-term follow-up. Patients and Methods FOXP3-…

Primary lung cancer samples of the major histological types were examined for expression
of the tumour suppressor gene p53 by immunohistochemistry. Abnormalities in p53 …