User profiles for Albert C. Koong

Albert Koong

MD Anderson Cancer Center
Verified email at mdanderson.org
Cited by 30413

XBP1 is essential for survival under hypoxic conditions and is required for tumor growth

…, NC Denko, AJ Giaccia, QT Le, AC Koong - Cancer research, 2004 - AACR
Hypoxia within solid tumors is a major determinant of outcome after anticancer therapy.
Analysis of gene expression changes during hypoxia indicated that unfolded protein response …

Pancreatic tumors show high levels of hypoxia

AC Koong, VK Mehta, QT Le, GA Fisher… - International Journal of …, 2000 - Elsevier
Purpose: Because of the dismal outcomes of conventional therapies for pancreatic carcinomas,
we postulated that hypoxia may exist within these tumors. Methods and Materials: Seven …

Hypoxia causes the activation of nuclear factor κB through the phosphorylation of IκBα on tyrosine residues

AC Koong, EY Chen, AJ Giaccia - Cancer research, 1994 - AACR
The response of mammalian cells to stress is controlled by transcriptional regulatory proteins
such as nuclear factor κB (NF-κB) to induce a wide variety of early response genes. In this …

Identification of an Ire1alpha endonuclease specific inhibitor with cytotoxic activity against human multiple myeloma

…, F Offner, M Niwa, AC Koong - Blood, The Journal …, 2011 - ashpublications.org
Activation of the adaptive Ire1-XBP1 pathway has been identified in many solid tumors and
hematologic malignancies, including multiple myeloma (MM). Here, we report the …

Phase I study of stereotactic radiosurgery in patients with locally advanced pancreatic cancer

AC Koong, QT Le, A Ho, B Fong, G Fisher… - International Journal of …, 2004 - Elsevier
PURPOSE: To determine the feasibility and toxicity of delivering stereotactic radiosurgery to
patients with locally advanced pancreatic cancer. METHODS AND MATERIALS: Patients …

Phase 2 multi‐institutional trial evaluating gemcitabine and stereotactic body radiotherapy for patients with locally advanced unresectable pancreatic adenocarcinoma

…, DA Laheru, LA Columbo, EA Sugar, AC Koong - Cancer, 2015 - Wiley Online Library
BACKGROUND This phase 2 multi‐institutional study was designed to determine whether
gemcitabine (GEM) with fractionated stereotactic body radiotherapy (SBRT) results in …

Stereotactic radiotherapy for unresectable adenocarcinoma of the pancreas

…, GA Fisher, JM Ford, T Desser, A Quon, AC Koong - Cancer, 2009 - Wiley Online Library
BACKGROUND: The authors report on the local control and toxicity of stereotactic body
radiotherapy (SBRT) for patients with unresectable pancreatic adenocarcinoma. METHODS: …

Candidate genes for the hypoxic tumor phenotype

AC Koong, NC Denko, KM Hudson, C Schindler… - Cancer research, 2000 - AACR
In this study, we have analyzed changes induced by hypoxia at the transcriptional level of
genes that could be responsible for a more aggressive phenotype. Using a series of DNA …

Circulating miR-210 as a novel hypoxia marker in pancreatic cancer

…, K Bennewith, QT Le, AC Koong - Translational …, 2010 - Elsevier
MicroRNA are small noncoding transcripts involved in many cellular mechanisms, including
tumorigenesis. miR-210, in particular, is induced by hypoxia and correlates with adverse …

Phase II study to assess the efficacy of conventionally fractionated radiotherapy followed by a stereotactic radiosurgery boost in patients with locally advanced …

AC Koong, E Christofferson, QT Le… - International Journal of …, 2005 - Elsevier
Purpose: To determine the efficacy of concurrent 5-fluorouracil (5-FU) and intensity-modulated
radiotherapy (IMRT) followed by body stereotactic radiosurgery (SRS) in patients with …