User profiles for Albert C. Koong
Albert KoongMD Anderson Cancer Center Verified email at mdanderson.org Cited by 30413 |
XBP1 is essential for survival under hypoxic conditions and is required for tumor growth
Hypoxia within solid tumors is a major determinant of outcome after anticancer therapy.
Analysis of gene expression changes during hypoxia indicated that unfolded protein response …
Analysis of gene expression changes during hypoxia indicated that unfolded protein response …
Pancreatic tumors show high levels of hypoxia
Purpose: Because of the dismal outcomes of conventional therapies for pancreatic carcinomas,
we postulated that hypoxia may exist within these tumors. Methods and Materials: Seven …
we postulated that hypoxia may exist within these tumors. Methods and Materials: Seven …
Hypoxia causes the activation of nuclear factor κB through the phosphorylation of IκBα on tyrosine residues
AC Koong, EY Chen, AJ Giaccia - Cancer research, 1994 - AACR
The response of mammalian cells to stress is controlled by transcriptional regulatory proteins
such as nuclear factor κB (NF-κB) to induce a wide variety of early response genes. In this …
such as nuclear factor κB (NF-κB) to induce a wide variety of early response genes. In this …
Identification of an Ire1alpha endonuclease specific inhibitor with cytotoxic activity against human multiple myeloma
Activation of the adaptive Ire1-XBP1 pathway has been identified in many solid tumors and
hematologic malignancies, including multiple myeloma (MM). Here, we report the …
hematologic malignancies, including multiple myeloma (MM). Here, we report the …
Phase I study of stereotactic radiosurgery in patients with locally advanced pancreatic cancer
PURPOSE: To determine the feasibility and toxicity of delivering stereotactic radiosurgery to
patients with locally advanced pancreatic cancer. METHODS AND MATERIALS: Patients …
patients with locally advanced pancreatic cancer. METHODS AND MATERIALS: Patients …
Phase 2 multi‐institutional trial evaluating gemcitabine and stereotactic body radiotherapy for patients with locally advanced unresectable pancreatic adenocarcinoma
…, DA Laheru, LA Columbo, EA Sugar, AC Koong - Cancer, 2015 - Wiley Online Library
BACKGROUND This phase 2 multi‐institutional study was designed to determine whether
gemcitabine (GEM) with fractionated stereotactic body radiotherapy (SBRT) results in …
gemcitabine (GEM) with fractionated stereotactic body radiotherapy (SBRT) results in …
Stereotactic radiotherapy for unresectable adenocarcinoma of the pancreas
BACKGROUND: The authors report on the local control and toxicity of stereotactic body
radiotherapy (SBRT) for patients with unresectable pancreatic adenocarcinoma. METHODS: …
radiotherapy (SBRT) for patients with unresectable pancreatic adenocarcinoma. METHODS: …
Candidate genes for the hypoxic tumor phenotype
In this study, we have analyzed changes induced by hypoxia at the transcriptional level of
genes that could be responsible for a more aggressive phenotype. Using a series of DNA …
genes that could be responsible for a more aggressive phenotype. Using a series of DNA …
Circulating miR-210 as a novel hypoxia marker in pancreatic cancer
MicroRNA are small noncoding transcripts involved in many cellular mechanisms, including
tumorigenesis. miR-210, in particular, is induced by hypoxia and correlates with adverse …
tumorigenesis. miR-210, in particular, is induced by hypoxia and correlates with adverse …
Phase II study to assess the efficacy of conventionally fractionated radiotherapy followed by a stereotactic radiosurgery boost in patients with locally advanced …
Purpose: To determine the efficacy of concurrent 5-fluorouracil (5-FU) and intensity-modulated
radiotherapy (IMRT) followed by body stereotactic radiosurgery (SRS) in patients with …
radiotherapy (IMRT) followed by body stereotactic radiosurgery (SRS) in patients with …