Dexfenfluramine was approved in the United States for long-term use as an appetite suppressant
until it was reported to be associated with valvular heart disease. The valvular changes …

N-methyl-d-aspartate receptors (NMDARs) are glutamate-gated ion channels that are critical
to the regulation of excitatory synaptic function in the CNS. NMDARs govern experience-…

The identification of small molecule aminohydantoins as potent and selective human β-secretase
inhibitors is reported. These analogues exhibit low nannomolar potency for BACE1, …

The identification of small molecule aminoimidazoles as potent and selective human β-secretase
inhibitors is reported. These analogues demonstrate low nannomolar potency for …

Zuranolone (SAGE-217) is a novel, synthetic, clinical stage neuroactive steroid GABA A
receptor positive allosteric modulator designed with the pharmacokinetic properties to support …

Conclusions The use of hydrogen bond interactions to direct selective mo-lecular recognition
processes of acyclic imides has been demonstrated by studying their cocrystallization …

We report the synthesis and structure–activity relationships of a class of tetracyclic butyrophenones
that exhibit potent binding affinities to serotonin 5-HT 2A and dopamine D 2 receptors…

Certain classes of neuroactive steroids (NASs) are positive allosteric modulators (PAM) of
synaptic and extrasynaptic GABA A receptors. Herein, we report new SAR insights in a series …

N-Methyl-d-aspartate receptor (NMDAR) positive allosteric modulators (PAMs) have received
increased interest as a powerful mechanism of action to provide relief as therapies for CNS …

… Robichaud. One-pot synthesis of highly substituted indolines. Tetrahedron 2010, 66 (3) ,
573-577. … Schechter, Albert J. Robichaud. A regiospecific synthesis of a series of 1-sulfonyl …