The classical antifolate N-{4-[(2,4-diamino-5-ethyl-7H-pyrrolo[2,3-d]pyrimidin-6-yl)sulfanyl]benzoyl}-l-glutamic
acid (2) and 15 nonclassical analogues (3−17) were synthesized as …

Classical antifolate analogues containing a novel furo [2, 3-d] pyrimidine ring system which
include 2V-[4-[N-[(2, 4-diaminofuro [2, 3-d] pyrimidin-5-yl) methyl] amino] benzoyl]-L-glutamic …

Variation of the bridge linking the heterocyclic ring and p-aminobenzoyl-L-glutamate
portions of our previously descibed classical2, 4-diaminofuro [2, 3-d] pyrimidines 1 and 2 are …

The proton-coupled folate transporter (PCFT) is a folate-proton symporter with an acidic pH
optimum, approximating the microenvironments of solid tumors. We tested 6-substituted …

To optimize dual receptor tyrosine kinase (RTK) and dihydrofolate reductase (DHFR)
inhibition, the E- and Z-isomers of 5-[2-(2-methoxyphenyl)prop-1-en-1-yl]furo[2,3-d]pyrimidine-2,4-…

This review summarizes the biology of the proton-coupled folate transporter (PCFT). PCFT
was identified in 2006 as the primary transporter for intestinal absorption of dietary folates, as …

Fifteen novel nonclassical and two classical 2,4-diamino-6-(benzylamino)pyrido[2,3-d]pyrimidine
antifolates were synthesized as potential inhibitors of Pneumocystis carinii, (pc) …

Thirteen 2,4-diamino-5-methyl-6-[(monosubstituted anilino)methyl]pyrido[2,3-d]pyrimidines 5−17
were synthesized as potential Pneumocystis carinii (pc) and Toxoplasma gondii (tg) …

A series of seven 2-amino-4-oxo-6-substituted thieno[2,3-d]pyrimidines with bridge length
variations (from 2 to 8 carbon atoms) were synthesized as selective folate receptor (FR) α and …

6-Substituted classical pyrrolo[2,3-d]pyrimidine antifolates with a three- to six-carbon bridge
between the heterocycle and the benzoyl-l-glutamate (compounds 2−5, respectively) were …