Oxaliplatin-induced damage of cellular DNA

…, MCS Herzig, B Arnett, WG Chapman, AV Trevino… - Molecular …, 2000 - ASPET
Damage to cellular DNA is believed to determine the antiproliferative properties of platinum (Pt)
drugs. This study characterized DNA damage by oxaliplatin, a diaminocyclohexane Pt …

[HTML][HTML] Staphylococcus aureus biofilms decrease osteoblast viability, inhibits osteogenic differentiation, and increases bone resorption in vitro

…, SK Hardy, RL Woodbury, AV Trevino… - BMC musculoskeletal …, 2013 - Springer
Background Osteomyelitis is a severe and often debilitating disease characterized by
inflammatory destruction of bone. Despite treatment, chronic infection often develops which is …

Human T-lymphotropic virus type 1 peptides in chimeric and multivalent constructs with promiscuous T-cell epitopes enhance immunogenicity and overcome genetic …

…, AM DiGeorge, SF Conrad, AV Trevino… - Journal of …, 1995 - Am Soc Microbiol
Conventional strategies of viral peptide immunizations often elicit low-affinity antibody responses
and have limited ability to elicit immune responses in outbred animals of diverse major …

[HTML][HTML] Identifying plasma derived extracellular vesicle (EV) contained biomarkers in the development of chronic neuropathic pain

…, G Dimitrov, S Srinivasan, A Gautam, AV Trevino… - The Journal of …, 2020 - Elsevier
Research into potentially novel biomarkers for chronic pain development is lacking.
microRNAs (miRNAs) are attractive candidates as biomarkers due to their conservation across …

[HTML][HTML] AT-rich Islands in Genomic DNA as a Novel Target for AT-specific DNA-reactive Antitumor Drugs* 210

JM Woynarowski, AV Trevino, KA Rodriguez… - Journal of Biological …, 2001 - ASBMB
Interstrand cross-links at T(A/T) 4 A sites in cellular DNA are associated with hypercytotoxicity
of an anticancer drug, bizelesin. Here we evaluated whether these lethal effects reflect …

Enhanced topoisomerase II targeting by annamycin and related 4-demethoxy anthracycline analogues

AV Trevino, BA Woynarowska, TS Herman… - Molecular cancer …, 2004 - AACR
Targeting topoisomerase II (topo II) is regarded as an important component of the pleiotropic
mechanism of action of anthracycline drugs. Here, we show that 4-demethoxy analogues of …

Enhanced human T-cell lymphotropic virus type I expression following induction of the cellular stress response

JM Andrews, MJ Oglesbee, AV Trevino, DJ Guyot… - Virology, 1995 - Elsevier
Human T-cell lymphotropic virus type I (HTLV-I) infection is typically associated with long
incubation periods between virus exposure and disease manifestation. Although viral protein …

Region-Specific DNA Damage by AT-Specific DNA-Reactive Drugs Is Predicted by Drug Binding Specificity,

JM Woynarowski, C Napier, AV Trevino, B Arnett - Biochemistry, 2000 - ACS Publications
Bizelesin and adozelesin are DNA-reactive antitumor drugs that alkylate adenines at the 3‘
ends of their preferred binding sites [5‘T(A/T) 4 A3‘and 5‘(A/T) 3 - 4 A3‘, respectively]. We …

Sound-stress-induced altered nociceptive behaviors are associated with increased spinal CRFR2 gene expression in a rat model of burn injury

NM Sosanya, AV Trevino, RL Chavez… - Journal of pain …, 2017 - Taylor & Francis
Sound stress (SS) elicits behavioral changes, including pain behaviors. However, the neuronal
mechanisms underlying SS-induced pain behaviors remain to be explored. The current …

Apoptosis induction by the dual-action DNA-and protein-reactive antitumor drug irofulven is largely Bcl-2-independent

MCS Herzig, AV Trevino, H Liang, R Salinas… - Biochemical …, 2003 - Elsevier
The overexpression of Bcl-2 is implicated in the resistance of cancer cells to apoptosis. This
study explored the potential of irofulven (hydroxymethylacylfulvene, HMAF, MGI 114, NSC …