Separate and combined glucometabolic effects of endogenous glucose-dependent insulinotropic polypeptide and glucagon-like peptide 1 in healthy individuals

…, MH Jensen, MBN Gabe, AH Sparre-Ulrich… - Diabetes, 2019 - Am Diabetes Assoc
The incretin hormones glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like
peptide 1 (GLP-1) are secreted postprandially and contribute importantly to postprandial …

[HTML][HTML] GIP(3-30)NH2 is an efficacious GIP receptor antagonist in humans: a randomised, double-blinded, placebo-controlled, crossover study

…, B Hartmann, AR Lanng, AH Sparre-Ulrich… - Diabetologia, 2018 - Springer
Aims/hypothesis Glucose-dependent insulinotropic polypeptide (GIP) is an incretin hormone
secreted postprandially from enteroendocrine K cells, but despite therapeutically interesting …

Glucose-dependent insulinotropic polypeptide augments glucagon responses to hypoglycemia in type 1 diabetes

M Christensen, S Calanna, AH Sparre-Ulrich… - Diabetes, 2015 - Am Diabetes Assoc
Glucose-dependent insulinotropic polypeptide (GIP) is glucagonotropic, and glucagon-like
peptide-1 (GLP-1) is glucagonostatic. We studied the effects of GIP and GLP-1 on glucagon …

Effects of endogenous GIP in patients with type 2 diabetes

…, K Skov-Jeppesen, AH Sparre-Ulrich… - European Journal of …, 2021 - academic.oup.com
Objective The insulinotropic effect of exogenous, intravenously infused glucose-dependent
insulinotropic polypeptide (GIP) is impaired in patients with type 2 diabetes. We evaluated …

GIP and GLP-1 receptor antagonism during a meal in healthy individuals

…, B Hartmann, AH Sparre-Ulrich… - The Journal of …, 2020 - academic.oup.com
Context The actions of both endogenous incretin hormones during a meal have not previously
been characterized. Objective Using specific receptor antagonists, we investigated the …

Partial functional complementation between human and mouse cytomegalovirus chemokine receptor homologues

…, AM Abraham, RD Cardin, AH Sparre-Ulrich… - Journal of …, 2011 - Am Soc Microbiol
The human cytomegalovirus (CMV) proteins US28 and UL33 are homologous to chemokine
receptors (CKRs). Knockout of the mouse CMV M33 protein (UL33 homologue) results in …

[PDF][PDF] Investigating GIPR (ant) agonism: a structural analysis of GIP and its receptor

…, M Lückmann, TN Hansen, AH Sparre-Ulrich… - Structure, 2021 - cell.com
The glucose-dependent insulinotropic polypeptide (GIP) is a 42-residue metabolic hormone
that is actively being targeted for its regulatory role of glycemia and energy balance. Limited …

Acute concomitant glucose‐dependent insulinotropic polypeptide receptor antagonism during glucagon‐like peptide 1 receptor agonism does not affect appetite …

S Stensen, LL Krogh, AH SparreUlrich… - Diabetes, Obesity …, 2022 - Wiley Online Library
1 BACKGROUND In type 2 diabetes (as well as other forms of diabetes), the insulinotropic
effect of exogenous glucose-dependent insulinotropic polypeptide (GIP) is markedly reduced …

Signaling via G proteins mediates tumorigenic effects of GPR87

KN Arfelt, S Fares, AH Sparre-Ulrich, GM Hjortø… - Cellular …, 2017 - Elsevier
G protein-coupled receptors (GPCRs) constitute a large protein family of seven transmembrane
(7TM) spanning proteins that regulate multiple physiological functions. GPR87 is …

Identification and functional comparison of seven-transmembrane G-protein-coupled BILF1 receptors in recently discovered nonhuman primate lymphocryptoviruses

K Spiess, S Fares, AH Sparre-Ulrich… - Journal of …, 2015 - Am Soc Microbiol
Coevolution of herpesviruses with their respective host has resulted in a delicate balance
between virus-encoded immune evasion mechanisms and host antiviral immunity. BILF1 …