User profiles for Alexander Storch

Alexander Storch

University of Rostock
Verified email at med.uni-rostock.de
Cited by 19524

Efficient generation of neural stem cell-like cells from adult human bone marrow stromal cells

…, J Schwarz, R Brenner, A Storch - Journal of cell …, 2004 - journals.biologists.com
Clonogenic neural stem cells (NSCs) are self-renewing cells that maintain the capacity to
differentiate into brain-specific cell types, and may also replace or repair diseased brain tissue. …

[PDF][PDF] Direct reprogramming of fibroblasts into neural stem cells by defined factors

…, JH Yang, HT Lee, JC Schwamborn, A Storch… - Cell stem cell, 2012 - cell.com
Recent studies have shown that defined sets of transcription factors can directly reprogram
differentiated somatic cells to a different differentiated cell type without passing through a …

Treadmill training for patients with Parkinson's disease

J Mehrholz, J Kugler, A Storch, M Pohl… - Cochrane database …, 2015 - cochranelibrary.com
Background Treadmill training is used in rehabilitation and is described as improving gait
parameters of patients with Parkinson's disease. Objectives To assess the effectiveness of …

Nonmotor fluctuations in Parkinson disease: severity and correlation with motor complications

A Storch, CB Schneider, M Wolz, Y Stürwald, A Nebe… - Neurology, 2013 - AAN Enterprises
Storch was responsible for study concept and design, acquisition of data, statistical analyses
and interpretation of data, chairing the NoMoFlu-PD steering committee, and drafting the …

A star-PEG–heparin hydrogel platform to aid cell replacement therapies for neurodegenerative diseases

…, W Panyanuwat, S Zschoche, D Meinhold, A Storch… - Biomaterials, 2009 - Elsevier
Biofunctional matrices for in vivo tissue engineering strategies must be modifiable in both
biomolecular composition and mechanical characteristics. To address this challenge, we …

Long-term proliferation and dopaminergic differentiation of human mesencephalic neural precursor cells

A Storch, G Paul, M Csete, BO Boehm, PM Carvey… - Experimental …, 2001 - Elsevier
We report on generation of dopamine neurons from long-term cultures of human fetal
mesencephalic precursor cells. These CNS precursor cells were successfully expanded in vitro …

Transcriptional Profiles of CD133+ and CD133 Glioblastoma-Derived Cancer Stem Cell Lines Suggest Different Cells of Origin

…, U Bogdahn, J Wischhusen, R Spang, A Storch… - Cancer research, 2010 - AACR
Glioblastoma multiforme (GBM) is paradigmatic for the investigation of cancer stem cells (CSC)
in solid tumors. Growing evidence suggests that different types of CSC lead to the …

Increased susceptibility to sporadic Parkinson's disease by a certain combined α‐synuclein/apolipoprotein E genotype

…, T Müller, N Kühnl, GA Fuchs, A Storch… - Annals of Neurology …, 1999 - Wiley Online Library
Parkinson's disease (PD) is one of the most common neurodegenerative disorders affecting
about 1% of Western populations older than age 50. The pathological hallmark of PD are …

Randomized, double-blind, placebo-controlled trial on symptomatic effects of coenzyme Q10 in Parkinson disease

A Storch, WH Jost, P Vieregge, J Spiegel… - Archives of …, 2007 - jamanetwork.com
Background Major hallmarks in the pathophysiology of Parkinson disease are cellular energy
depletion and oxidative stress leading to cellular dysfunction and death. Coenzyme Q 10 (…

[HTML][HTML] Impaired DNA damage response signaling by FUS-NLS mutations leads to neurodegeneration and FUS aggregate formation

…, F Wegner, SW Grill, J Weis, A Storch… - Nature …, 2018 - nature.com
Amyotrophic lateral sclerosis (ALS) is the most frequent motor neuron disease. Cytoplasmic
fused in sarcoma (FUS) aggregates are pathological hallmarks of FUS-ALS. Proper shuttling …