Drug resistance in African trypanosomes has been studied for almost a hundred years.
Beginning with Paul Ehrlich’s work that led to the chemoreceptor hypothesis, reduction of net …

Trypanosoma brucei are unicellular parasites that cause sleeping sickness in humans and
nagana in livestock. Trypanosomes salvage purines from their hosts through a variety of …

Trypanosoma brucei encodes a relatively high number of genes of the equilibrative nucleoside
transporter (ENT) family. We report here the cloning and in-depth characterization of one …

Trypanosoma brucei cannot synthesize purines de novo and relies on purine salvage from
its hosts to build nucleic acids. With adenosine being a preferred purine source of …

African trypanosomes, like all obligate parasitic protozoa, cannot synthesize purines de novo
and import purines from their hosts to build nucleic acids. The purine salvage pathways of …

Melarsoprol is a melamine-based arsenical that was developed against sleeping sickness
which is still the only drug approved for treatment of late-stage sleeping sickness that is active …

The molecular mechanisms of K + homeostasis are only poorly understood for protozoan
parasites. Trypanosoma brucei subsp. parasites, the causative agents of human sleeping …

31 African trypanosomes, like all obligate parasitic protozoa, cannot synthesize purines de
novo and import 32 purines from their hosts to build nucleic acids. The purine salvage …

Despite the rapidly-increasing widespread adoption of percussive therapy as a tool for pain
management by individual consumers and health professionals alike, relatively little …

Malaria caused by Plasmodium falciparum is still a major health problem in many tropical
countries infecting 500 million people leading to 1 to 2 millions of deaths annually. An effective …