Dopamine in prefrontal cortices is implicated in cognitive and emotional functions, and the
dysfunction of prefrontal dopamine has been associated with cognitive and emotional deficits …

G protein-coupled receptors are key signaling molecules and major targets for pharmaceuticals.
The concept of ligand-dependent biased signaling raises the possibility of developing …

Orphan G-protein-coupled receptors (oGPCRs) possess untapped potential for drug discovery.
In the brain, oGPCRs are generally expressed at low abundance and their function is …

Introduction: Pain relief remains a major public health challenge. The most efficient available
painkillers are opioids targeting the mu opioid receptor (MOR). MORs are expressed in the …

The anterior cingulate cortex (ACC) processes the affective component of pain, whereas the
primary somatosensory cortex (S1) is involved in its sensory-discriminative component. …

GPR88 is an orphan G-protein coupled receptor originally characterized as a striatal-enriched
transcript and is a potential target for neuropsychiatric disorders. At present, gene …

Oxycodone is a potent medicinal opioid analgesic to treat pain. It is also addictive and a
main cause for the current opioid crisis. At present, the impact of oxycodone on coordinated …

Introduction Tianeptine is approved in some countries to treat depression and anxiety. In
addition to its activity on serotonin and glutamate neurotransmission, tianeptine has been …

The atypical chemokine receptor 3, ACKR3, is a G protein-coupled receptor, which does not
couple to G proteins but recruits βarrestins. At present, ACKR3 is considered a target for …

The mechanism underlying the crosstalk between multiple G protein–coupled receptors
remains poorly understood. We previously reported that prostaglandin E receptor EP1 facilitates …